Aims Elevation of arginase activity has been linked to vascular dysfunction in diabetes and
hypertension by a mechanism involving decreased nitric oxide (NO) bioavailability due to L …

Arginase can cause vascular dysfunction by competing with nitric oxide synthase for l-
arginine and by increasing cell proliferation and collagen formation, which promote vascular …

Arginase may play a major role in the regulation of vascular function in various
cardiovascular disorders by impairing nitric oxide (NO) production. In the current study, we …

Objective This study investigated whether arginase contributes to endothelial dysfunction
and hypertension in obese rats. Methods Endothelial function and arginase expression were …

Background Elevated arginase (Arg) activity is reported to be involved in diabetes-induced
vascular endothelial dysfunction. It can reduce L-arginine availability to nitric oxide (NO) …

Diabetes mellitus is a major risk factor for the development of cardiovascular disease due to
increased vascular inflammatory and oxidative stress favouring atherogenesis. Endothelial …

Background Cardiovascular disorders associated with endothelial dysfunction, such as
atherosclerosis, have decreased nitric oxide (NO) bioavailability. Arginase in the vasculature …

Obesity-induced vascular dysfunction involves pathological remodeling of the visceral
adipose tissue (VAT) and increased inflammation. Our previous studies showed that …

Background: Endothelial dysfunction contributes to the development of vascular
complication in diabetes. Arginase has emerged as a key mechanism behind endothelial …

Background—Although abnormal l-arginine NO signaling contributes to endothelial
dysfunction in the aging cardiovascular system, the biochemical mechanisms remain …