Background and purpose Predicting the efficacy of anticancer therapy is the holy grail of
drug development and treatment selection in the clinic. To achieve this goal, scientists …

Molecularly targeted treatments and immunotherapy are cornerstones in oncology, with
demonstrated efficacy across different tumor types. Nevertheless, the overwhelming majority …

Precision medicine approaches have revolutionized oncology. Personalized treatments
require not only identification of the driving molecular alterations, but also development of …

Although cancer research is progressing at an exponential rate, translating this knowledge
to develop better cancer drugs and more effectively match drugs to patients is lagging …

Recent progress in understanding the molecular basis of cellular processes, identification of
promising therapeutic targets and evolution of the regulatory landscape makes this an …

The future of cancer treatment lies in personalized strategies designed to specifically target
tumorigenic cell populations present in an individual. Although recent advances in directed …

Precision medicine is an approach that takes into account the influence of individuals'
genes, environment, and lifestyle exposures to tailor interventions. Here, we describe the …

Precision cancer medicine is based on the ability to predict the dependencies of a given
tumor from its molecular makeup. These dependencies can be exploited with targeted …

Simple Summary It was found that long-established tumor-derived cell lines do not
adequately reproduce drug sensitivity and behavior of a real human cancers. Therefore …

Predictive tools, utilising biomarkers, aim to objectively assess the potential response to a
particular clinical intervention in order to direct treatment. Conventional cancer therapy …