The FXG: a presynaptic fragile X granule expressed in a subset of developing brain circuits

SB Christie, MR Akins, JE Schwob… - Journal of …, 2009 - Soc Neuroscience
The loss of Fragile X mental retardation protein (FMRP) causes Fragile X syndrome, the
most common inherited mental retardation and single gene cause of autism. Although …

Systematic mapping of fragile X granules in the mouse brain reveals a potential role for presynaptic FMRP in sensorimotor functions

MR Akins, HF LeBlanc, EE Stackpole… - Journal of …, 2012 - Wiley Online Library
Loss of Fragile X mental retardation protein (FMRP) leads to Fragile X syndrome (FXS), the
most common form of inherited intellectual disability and autism. Although the functions of …

Cellular distribution of the fragile X mental retardation protein in the mouse brain

DAR Zorio, CM Jackson, Y Liu… - Journal of …, 2017 - Wiley Online Library
The fragile X mental retardation protein (FMRP) plays an important role in normal brain
development. Absence of FMRP results in abnormal neuronal morphologies in a selected …

Fragile X proteins FMRP and FXR2P control synaptic GluA1 expression and neuronal maturation via distinct mechanisms

W Guo, ED Polich, J Su, Y Gao, DM Christopher… - Cell reports, 2015 - cell.com
Fragile X mental retardation protein (FMRP) and its autosomal paralog FXR2P are selective
neuronal RNA-binding proteins, and mice that lack either protein exhibit cognitive deficits …

The molecular biology of FMRP: new insights into fragile X syndrome

JD Richter, X Zhao - Nature Reviews Neuroscience, 2021 - nature.com
Fragile X mental retardation protein (FMRP) is the product of the fragile X mental retardation
1 gene (FMR1), a gene that—when epigenetically inactivated by a triplet nucleotide repeat …

Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P

RL Coffee Jr, CR Tessier… - Disease models & …, 2010 - journals.biologists.com
Fragile X syndrome (FXS), resulting solely from the loss of function of the human fragile X
mental retardation 1 (hFMR1) gene, is the most common heritable cause of mental …

Independent role for presynaptic FMRP revealed by an FMR1 missense mutation associated with intellectual disability and seizures

LK Myrick, PY Deng, H Hashimoto… - Proceedings of the …, 2015 - National Acad Sciences
Fragile X syndrome (FXS) results in intellectual disability (ID) most often caused by silencing
of the fragile X mental retardation 1 (FMR1) gene. The resulting absence of fragile X mental …

Fragile X mental retardation protein induces synapse loss through acute postsynaptic translational regulation

BE Pfeiffer, KM Huber - Journal of neuroscience, 2007 - Soc Neuroscience
Fragile X syndrome, as well as other forms of mental retardation and autism, is associated
with altered dendritic spine number and structure. Fragile X syndrome is caused by loss-of …

Heads‐up: New roles for the fragile X mental retardation protein in neural stem and progenitor cells

MA Callan, DC Zarnescu - Genesis, 2011 - Wiley Online Library
Fragile X syndrome (FXS) is the most common form of inherited mental retardation and is
caused by the loss of function for Fragile X Mental Retardation Protein (FMRP), a selective …

The state of synapses in fragile X syndrome

BE Pfeiffer, KM Huber - The Neuroscientist, 2009 - journals.sagepub.com
Fragile X syndrome (FXS) is the most common inherited form of mental retardation and a
leading genetic cause of autism. There is increasing evidence in both FXS and other forms …