Understanding the mechanisms of neuronal regeneration and repair in the adult central
nervous system is a vital area of research. Using a rhesus lentiviral encephalitis model, we …

The prevalence of central nervous system (CNS) neurologic dysfunction associated with
human immunodeficiency virus (HIV) infection continues to increase, despite the use of …

Neuronal damage induced by ongoing human immunodeficiency virus type 1 (HIV-1)
infection was investigated in humanized NOD/scid-IL-2Rγcnull mice transplanted at birth …

Objective: Postmortem brains of patients diagnosed with HIV-1-associated neurocognitive
disorders (HAND) exhibit loss of dendrites. However, the mechanisms by which synapses …

Cortical function is disrupted in neuroinflammatory disorders, including HIV-associated
neurocognitive disorders (HAND). Astrocyte dysfunction includes retraction of foot processes …

Simian immunodeficiency virus (SIV) infection of pigtailed macaques is a highly
representative and well-characterized animal model for HIV neuropathogenesis studies that …

Human immunodeficiency virus type-1 (HIV) causes mild or severe neurological problems,
termed HIV-associated neurocognitive disorder (HAND), even when HIV patients receive …

Virus-induced accelerated aging has been proposed as a potential mechanism underlying
the persistence of HIV-associated neurocognitive disorders (HAND) despite advances in …

Primary human neuron cultures are an important in vitro model system for studies on
mechanisms involved in human immunodeficiency virus (HIV)-associated dementia (HAD) …

Despite antiretroviral therapy (ART), HIV-associated peripheral neuropathy remains one of
the most prevalent neurologic manifestations of HIV infection. The spinal cord is an essential …