Homozygous mutations in exon 2 of TREM2, a gene involved in Nasu-Hakola disease, can
cause frontotemporal dementia (FTD). Moreover, a rare TREM2 exon 2 variant (p. R47H) …

TREM2 (triggering receptor expressed on myeloid cells 2) gene variants were reported to
increase the risk of Alzheimer's disease (AD) and even other neurodegenerative diseases …

A non-synonymous genetic rare variant, rs75932628-T (p. R47H), in the TREM2 gene has
recently been reported to be a strong genetic risk factor for Alzheimer's disease (AD). Also …

A rare variant in TREM2 (p. R47H, rs75932628) was recently reported to increase the risk of
Alzheimer's disease (AD) and, subsequently, other neurodegenerative diseases, ie …

Background Homozygous loss-of-function mutations in TREM2, encoding the triggering
receptor expressed on myeloid cells 2 protein, have previously been associated with an …

Rare variation in TREM2 has been associated with greater risk for Alzheimer's disease (AD).
TREM2 encodes a cell surface receptor expressed on microglia and related cells, and the …

Background Rare TREM2 variants are significant risk factors for Alzheimer's disease (AD).
Methods We used next generation sequencing of the whole gene (n= 700), exon 2 Sanger …

Objectives: Recently, 2 independent studies reported that a rare missense variant,
rs75932628 (R47H), in exon 2 of the gene encoding the “triggering receptor expressed on …

The triggering receptor expressed on myeloid 2 (TREM2) is an immune phagocytic receptor
expressed on brain microglia known to trigger phagocytosis and regulate the inflammatory …

Rare non-synonymous variants of TREM2 have recently been shown to be associated with
Alzheimer's disease (AD) in Caucasians. We here conducted a replication study using a well …