Parietal cells (PCs) produce gastric acid to kill pathogens and aid digestion. Dysregulated
PC census is common in disease, yet how PCs differentiate is unclear. Here, we identify the …

Defects in gastric progenitor cell differentiation are associated with various gastric disorders,
including atrophic gastritis, intestinal metaplasia, and gastric cancer. However, the …

Adult gastric stem cells replenish the gastric epithelium throughout life. Recent studies have
identified diverse populations of stem cells, progenitor cells, and even differentiated cells …

Gastric epithelium operates in a hazardous environment that curtails the lifespan of the
constituent cells, imposing a requirement for continuous epithelial renewal. Stem cells that …

The epithelial lining of the stomach undergoes rapid turnover to preserve its structural and
functional integrity, a process driven by long-lived stem cells residing in the antral and …

The pyloric epithelium continuously self-renews throughout life, driven by limited reservoirs
of resident Lgr5+ adult stem cells. Here, we characterize the population dynamics of these …

The stomach, an organ derived from foregut endoderm, secretes acid and enzymes and
plays a key role in digestion. During development, mesenchymal-epithelial interactions drive …

The stem/progenitor cell pool is indispensable for the development, homeostasis and
regeneration of the gastric epithelium, owing to its defining ability to self-renew whilst …

The stomach epithelium contains a myriad of enteroendocrine cells that modulate a range of
physiological functions, including postprandial secretion of regulatory peptides, gastric …

Cellular metabolism plays important functions in dictating stem cell behaviors, although its
role in stomach epithelial homeostasis has not been evaluated in depth. Here, we show that …