Background Myocardial fibrosis is a common pathological manifestation of many
cardiovascular diseases at the end stage. Autophagy has been demonstrated to play a …

Heart disease is a significant health concern for elderly individuals, with heart aging being
the primary cause. Recent studies have shown that autophagy can play a protective role in …

Hyperglycemia-induced reactive oxygen species (ROS) generation and Ca2+ overload
contribute to the development of diabetic cardiomyopathy. In this study, we aimed to study …

Abstract Ethnopharmacological relevance Si-Miao-Yong-An decoction (SMYAD) is a
traditional Chinese herbal formulation. SMYAD first appeared in the Eastern Han Dynasty …

Background Cardiac hypertrophy is the early stage of many heart diseases, such as
coronary heart disease, hypertension, valvular dysfunction and cardiomyopathy …

Abstract Ethnopharmacological relevance Panax notoginseng (Burkill) FH Chen
(Araliaceae) has a long history of clinical application in China for the treatment of …

Epigallocatechin-3-gallate (EGCG) possesses anti-fibrotic potential in diverse tissues;
however, the molecular mechanisms underlying the impacts of EGCG on diabetes-induced …

Background The pathogenesis of myocardial ischemia/reperfusion is complex, involving
multiple regulatory genes and environmental factors, and requiring the simultaneous …

Methods: We constructed a rat model of myocardial injury and compared among 4 groups
(n= 10, each): the sham-operated group (Sham), the ischemia-reperfusion group (IR), the …

Astragalus membranaceus is a traditional Chinese medicine and has been widely used in
treating cardiovascular diseases (CVDs), such as asthma, edema, and chest tightness …