Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling

L Wang, D Yuan, J Zheng, X Wu, J Wang, X Liu, Y He… - Phytomedicine, 2019 - Elsevier
Background Myocardial fibrosis is a common pathological manifestation of many
cardiovascular diseases at the end stage. Autophagy has been demonstrated to play a …

[HTML][HTML] Saponins of Panax japonicus ameliorates cardiac aging phenotype in aging rats by enhancing basal autophagy through AMPK/mTOR/ULK1 pathway

H Huang, T Wang, L Wang, Y Huang, W Li, Y Hu… - Experimental …, 2023 - Elsevier
Heart disease is a significant health concern for elderly individuals, with heart aging being
the primary cause. Recent studies have shown that autophagy can play a protective role in …

Chikusetsu saponin IVa confers cardioprotection via SIRT1/ERK1/2 and Homer1a pathway

J Duan, Y Yin, G Wei, J Cui, E Zhang, Y Guan, J Yan… - Scientific reports, 2015 - nature.com
Hyperglycemia-induced reactive oxygen species (ROS) generation and Ca2+ overload
contribute to the development of diabetic cardiomyopathy. In this study, we aimed to study …

Dissection of mechanisms of Chinese medicinal formula Si-Miao-Yong-an decoction protects against cardiac hypertrophy and fibrosis in isoprenaline-induced heart …

Y Zhao, Y Jiang, Y Chen, F Zhang, X Zhang… - Journal of …, 2020 - Elsevier
Abstract Ethnopharmacological relevance Si-Miao-Yong-An decoction (SMYAD) is a
traditional Chinese herbal formulation. SMYAD first appeared in the Eastern Han Dynasty …

Plantago asiatica L. seeds extract protects against cardiomyocyte injury in isoproterenol-induced cardiac hypertrophy by inhibiting excessive autophagy and apoptosis …

W Fan, B Zhang, C Wu, H Wu, J Wu, S Wu, J Zhang… - Phytomedicine, 2021 - Elsevier
Background Cardiac hypertrophy is the early stage of many heart diseases, such as
coronary heart disease, hypertension, valvular dysfunction and cardiomyopathy …

miR-29c is implicated in the cardioprotective activity of Panax notoginseng saponins against isoproterenol-induced myocardial fibrogenesis

L Liu, B Ning, J Cui, T Zhang, Y Chen - Journal of ethnopharmacology, 2017 - Elsevier
Abstract Ethnopharmacological relevance Panax notoginseng (Burkill) FH Chen
(Araliaceae) has a long history of clinical application in China for the treatment of …

Epigallocatechin-3-gallate attenuates myocardial fibrosis in diabetic rats by activating autophagy

Q Jia, R Yang, S Mehmood, Y Li - Experimental Biology and …, 2022 - journals.sagepub.com
Epigallocatechin-3-gallate (EGCG) possesses anti-fibrotic potential in diverse tissues;
however, the molecular mechanisms underlying the impacts of EGCG on diabetes-induced …

[HTML][HTML] Shexiang Baoxin Pill attenuates myocardial ischemia/reperfusion injury by activating autophagy via modulating the ceRNA-Map3k8 pathway

YW Yu, S Liu, YY Zhou, KY Huang, BS Wu, ZH Lin… - Phytomedicine, 2022 - Elsevier
Background The pathogenesis of myocardial ischemia/reperfusion is complex, involving
multiple regulatory genes and environmental factors, and requiring the simultaneous …

Panax notoginseng saponins attenuate myocardial ischemia-reperfusion injury through the HIF-1α/BNIP3 pathway of autophagy

XW Liu, MK Lu, HT Zhong, LH Wang… - Journal of …, 2019 - journals.lww.com
Methods: We constructed a rat model of myocardial injury and compared among 4 groups
(n= 10, each): the sham-operated group (Sham), the ischemia-reperfusion group (IR), the …

Astragaloside IV attenuate MI-induced myocardial fibrosis and cardiac remodeling by inhibiting ROS/caspase-1/GSDMD signaling pathway

X Zhang, H Qu, T Yang, Q Liu, H Zhou - Cell Cycle, 2022 - Taylor & Francis
Astragalus membranaceus is a traditional Chinese medicine and has been widely used in
treating cardiovascular diseases (CVDs), such as asthma, edema, and chest tightness …