Primary hepatocellular carcinoma (HCC) often invades into vessels and has a distal
metastasis at an early stage, resulting in poor prognosis and therapeutic outcome. The …

Cancer stem cells (CSCs) are cells possessing abilities of self-renewal, differentiation, and
tumorigenicity in NOD/SCID mice. Based on this definition, multiple cell surface markers …

Background Because few definitive markers are available for hepatic cancer stem cells
(HCSCs), based on physical rather than immunochemical properties, we applied a novel …

Hepatocellular carcinoma (HCC) is a major primary liver malignancy in adults. Despite the
progress made, the outcome of the treatment to this disease is less than satisfactory as the …

Aim: Hepatic stem cells are capable of dramatically changing and differentiating to form
mature hepatocytes in acute and chronically damaged livers; however, the …

The cancer stem cell (CSC) hypothesis was first proposed over 40 years ago. Advances in
CSC isolation were first achieved in hematological malignancies, with the first CSC …

Abstract Background and Aim: Recent investigations demonstrate that adult stem cells may
be targets for malignant transformation and that the stem‐like cells in diseased livers …

The cancer stem cell (CSC) hypothesis was proposed over 4 decades ago and states that
tumor growth is maintained by a small subset of cancer cells analogous to normal tissue …

Much controversy surrounds the identity and origin of human hepatic stem and progenitor
cells in part because of a lack of small animal models in which the developmental potential …

Several studies suggested the presence of stem cells in the adult normal human liver;
however, a population with stem cell properties has not yet been isolated. The purpose of …