The substantial heterogeneity and hierarchical organization in liver cancer support the
theory of liver cancer stem cells (LCSCs). However, the relationship between chronic …

BACKGROUND/AIMS: We attempted to establish an ex vivo model for transdifferentiation of
hematopoietic stem cells (HSCs) into functional hepatocytes for transplantation into healthy …

Liver transplantation is severely limited by donor shortage although it is the only effective
treatment for end-stage liver disease. So the best alternative is hepatocyte transplantation …

Liver cancer is an aggressive disease with a high mortality rate. Management of liver cancer
is strongly dependent on the tumor stage and underlying liver disease. Unfortunately, most …

Given the liver's remarkable and unique regenerative capacity, researchers have long
focused on liver progenitor cells (LPCs) and liver cancer stem cells (LCSCs). LPCs can …

Cancer stem cells (CSCs) are subpopulations of cells with stem cell characteristics that
produce both cancerous and non-tumorigenic cells in tumor tissues. The literature reports …

Numerous studies point to the fact that liver tumors are derived from single cells
(monoclonal), but the important question is, which cell? Stem cell biology and cancer are …

It is currently accepted that adult tissues may develop and maintain their own stem cell
pools. Because of their higher safety profile, adult stem cells may represent an ideal …

Hepatic stem cells can be identified by the expression of putative markers such as CD117 (c-
kit), CD90 (Thy-1), CD34, and HLA-DR. We have identified populations expressing these …

Liver progenitor cells have drawn a great deal of attention both for their therapeutic potential
and for their usefulness in exploring the molecular events surrounding liver development …