To assess the feasibility of using sandwich-cultured human hepatocytes (SCHHs) as a
model to characterize transport kinetics for in vivo pharmacokinetic prediction, the …

Hepatobiliary transport mechanisms have been identified to play a significant role in
determining the systemic clearance for a number of widely prescribed drugs and an …

Hepatic uptake transporters [solute carriers (SLCs)], including organic anion transporting
polypeptide (OATP) 1B1, OATP1B3, OATP2B1, sodium-dependent taurocholate …

Objectives Membrane transporters and metabolism are major determinants of the
hepatobiliary elimination of drugs. This work investigates several key questions for drug …

Introduction: Membrane transporters have been recognized to play a key role in determining
the absorption, distribution and elimination processes of drugs. The organic anion …

ABSTRACT Introduction: Drug-drug interactions (DDIs) continue to account for 5% of
hospital admissions and therefore remain a major regulatory concern. Effective, quantitative …

A thorough understanding of species-dependent differences in hepatic uptake transporters
is critical for predicting human pharmacokinetics (PKs) from preclinical data. In this study, the …

Drug biliary clearance (CLbile) in vivo is among the most difficult pharmacokinetic
parameters to predict accurately and quantitatively because biliary excretion is influenced by …

The ability to predict hepatic metabolic clearance is a key component in the design and
selection of small molecule drug candidates within the pharmaceutical industry. The …

Transporter-mediated hepatic uptake is proven to be the rate-determining step in the
systemic clearance of several drugs. Therefore, accurate measurement of active and …