The role of membrane transporters on pharmacokinetics (PKs), drug–drug interactions
(DDIs), pharmacodynamics (PDs), and toxicity of drugs has been broadly recognized …

Organic anion transporting polypeptide 1B1 plays a pivotal role in the disposition of many
anionic drugs. Significant overlap in substrate specificity between individual OATP isoforms …

Drug transporters are recognized widely for their role in clinical pharmacokinetics and drug–
drug interactions (DDIs). This has provided impetus to the inclusion of transporter substrate …

Various endogenous probes have been identified for a number of hepatic and renal drug
transporters and available clinical data indicate that they could be leveraged in phase I trials …

Variations in drug transporter activities, caused by genetic polymorphism and drug–drug
interactions (DDIs), alter the systemic exposure of substrate drugs, leading to differences in …

Hepatic uptake clearance has been measured in suspended human hepatocytes (SHH).
Plated human hepatocytes (PHH) after short-term culturing are increasingly employed to …

In the present investigations, we evaluate in vitro hepatocyte uptake and partitioning for the
prediction of in vivo clearance and liver partitioning. Monkeys were intravenously co-dosed …

Clearance (CL) prediction remains a significant challenge in drug discovery, especially
when complex processes such as drug transporters are involved. The present work explores …

Drug transporters are widely expressed in organs and tissue barriers throughout human and
animal bodies. Studies over the last two decades have identified various ATP-binding …

The accurate prediction of human pharmacokinetics is critically important in modern drug
discovery since it drives both pharmacological and toxicological effects. Although significant …