Colloidal nanosystems with mucoadhesive properties designed for ocular topical delivery

B Silva, B São Braz, E Delgado, L Gonçalves - International Journal of …, 2021 - Elsevier
Over the last years, the scientific interest about topical ocular delivery targeting the posterior
segment of the eye has been increasing. This is probably due to the fact that this is a non …

Applications of polymeric and lipid nanoparticles in ophthalmic pharmaceutical formulations: present and future considerations

H Almeida, MH Amaral, P Lobão… - … of Pharmacy & …, 2014 - journals.library.ualberta.ca
The unique properties and characteristics of ocular tissues and the whole set of defence
mechanisms of the ocular globe make the instillation of ocular drugs into a difficult task with …

Ocular drug delivery-new strategies for targeting anterior and posterior segments of the eye

JF Fangueiro, F Veiga, AM Silva… - Current pharmaceutical …, 2016 - ingentaconnect.com
The ocular delivery of drugs encounters several limitations because of the dynamic and
static barriers of the human's eye anatomy and physiology. The poor bioavailability of drugs …

Nanomaterials for ocular drug delivery

S Liu, L Jones, FX Gu - Macromolecular bioscience, 2012 - Wiley Online Library
Efficient drug delivery to the eye remains a challenging task for pharmaceutical scientists.
Due to the various anatomical barriers and the clearance mechanisms prevailing in the eye …

Ocular drug delivery to the anterior segment using nanocarriers: A mucoadhesive/mucopenetrative perspective

RS Dave, TC Goostrey, M Ziolkowska… - Journal of Controlled …, 2021 - Elsevier
There is a growing demand for effective treatments for ocular conditions that improve patient
compliance and reduce side-effects. While methods such as implants and injections have …

Mucoadhesive micro-/nano carriers in ophthalmic drug delivery: an overview

JB Naik, SR Pardeshi, RP Patil, PB Patil, A Mujumdar - BioNanoScience, 2020 - Springer
The eye is a challenging organ for ophthalmic drug delivery due to the barriers associated
with the anterior and posterior segments like nasolacrimal drainage, blinking, induced …

Strategies for improving ocular drug bioavailability and corneal wound healing with chitosan-based delivery systems

T Irimia, MV Ghica, L Popa, V Anuţa, AL Arsene… - Polymers, 2018 - mdpi.com
The main inconvenience of conventional eye drops is the rapid washout of the drugs due to
nasolacrimal drainage or ophthalmic barriers. The ocular drug bioavailability can be …

[HTML][HTML] Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases

AL Onugwu, CS Nwagwu, OS Onugwu… - Journal of Controlled …, 2023 - Elsevier
Diseases affecting the anterior segment of the eye are the primary causes of vision
impairment and blindness globally. Drug administration through the topical ocular route is …

Polymer-based carriers for ophthalmic drug delivery

JC Imperiale, GB Acosta, A Sosnik - Journal of controlled release, 2018 - Elsevier
Despite the wide range of diseases affecting the eye, ocular bioavailability remains a
challenge in ophthalmic drug delivery. Nowadays an extensive variety of polymers are being …

Nanoparticles for ocular drug delivery: Modified and non-modified chitosan as a promising biocompatible carrier

ARN Pontillo, A Detsi - Nanomedicine, 2019 - Taylor & Francis
The eye is a very important, yet sensitive organ, presenting complex anatomy. To overcome
its protective mechanisms, with the aim of improving drug delivery, drug encapsulation in …