Alternative splicing is one of the most important mechanisms to generate a large number of
mRNA and protein isoforms from the surprisingly low number of human genes. Unlike …

Recent analyses of sequence and microarray data have suggested that alternative splicing
plays a major role in the generation of proteomic and functional diversity in metazoan …

Alternative splicing of mRNA precursors provides an important means of genetic control and
is a crucial step in the expression of most genes. Alternative splicing markedly affects human …

Recent findings justify a renewed interest in alternative splicing (AS): the process is more a
rule than an exception as it affects the expression of 60% of human genes; it explains how a …

Following the original reports of pre‐mRNA splicing in 1977, it was quickly realized that
splicing together of different combinations of splice sites–alternative splicing–allows …

Alternative splicing (AS) is an important mechanism used to generate greater transcriptomic
and proteomic diversity from a finite genome. Nearly all human gene transcripts are …

Alternative splicing (AS) strongly affects gene expression by generating protein isoform
diversity. However, up to one-third of human AS events create a premature termination …

Alternative splicing is an important mechanism for controlling gene expression. It allows
large proteomic complexity from a limited number of genes. An interplay of cis-acting …

Alternative splicing of pre-mRNA is a key mechanism for increasing the complexity of
proteins in humans, causing a diversity of expression of transcriptomes and proteomes in a …

Alternative splicing affects more than 95% of multi-exon genes in the human genome. These
changes affect the proteome in a myriad of ways. Here, we review our understanding of the …