Prediction of severity of drug-drug interactions caused by enzyme inhibition and activation

A Dmitriev, D Filimonov, A Lagunin, D Karasev… - Molecules, 2019 - mdpi.com
Drug-drug interactions (DDIs) severity assessment is a crucial problem because
polypharmacy is increasingly common in modern medical practice. Many DDIs are caused …

Drug-drug interaction prediction using PASS

AV Dmitriev, DA Filimonov, AV Rudik… - SAR and QSAR in …, 2019 - Taylor & Francis
Simultaneous use of the drugs may lead to undesirable Drug-Drug Interactions (DDIs) in the
human body. Many DDIs are associated with changes in drug metabolism that performed by …

Metabolic-based drug-drug interactions prediction, recent approaches for risk assessment along drug development

X Boulenc, O Barberan - 2011 - degruyter.com
Prediction of in vivo drug-drug interactions (DDIs) from in vitro and in vivo data, also named
in vitro in vivo extrapolation (IVIVE), is of interest to scientists involved in the discovery and …

A proposal for a pharmacokinetic interaction significance classification system (PISCS) based on predicted drug exposure changes and its potential application to alert …

A Hisaka, M Kusama, Y Ohno, Y Sugiyama… - Clinical …, 2009 - Springer
Abstract Background and Objective Pharmacokinetic drug-drug interactions (DDIs) are one
of the major causes of adverse events in pharmacotherapy, and systematic prediction of the …

Prediction of drug-drug interactions related to inhibition or induction of drug-metabolizing enzymes

AV Dmitriev, AA Lagunin, DA Karasev… - Current Topics in …, 2019 - ingentaconnect.com
Drug-drug interaction (DDI) is the phenomenon of alteration of the pharmacological activity
of a drug (s) when another drug (s) is co-administered in cases of so-called polypharmacy …

CYP inhibition-mediated drug-drug interactions

K Tihanyi, ML Bakk, E Hellinger… - Current Enzyme …, 2010 - ingentaconnect.com
Adverse drug reaction is a frequent cause of drug withdrawals from the market. The drug-
drug interaction (DDI) potential of new drug candidates is an increasing safety concern of …

Does DDI-predictor help pharmacists to detect drug-drug interactions and resolve medication issues more effectively?

F Moreau, N Simon, J Walther, M Dambrine… - Metabolites, 2021 - mdpi.com
The characterization of drug-drug interactions (DDIs) may require the use of several different
tools, such as the thesaurus issued by our national health agency (ie, ANSM), the metabolic …

[HTML][HTML] Computerized techniques pave the way for drug-drug interaction prediction and interpretation

R Safdari, R Ferdousi, K Aziziheris… - BioImpacts …, 2016 - ncbi.nlm.nih.gov
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Introduction: Health care industry also patients penalized by medical errors that are …

In silico prediction of drug–drug interactions mediated by cytochrome P450 isoforms

AV Dmitriev, AV Rudik, DA Karasev, PV Pogodin… - Pharmaceutics, 2021 - mdpi.com
Drug–drug interactions (DDIs) can cause drug toxicities, reduced pharmacological effects,
and adverse drug reactions. Studies aiming to determine the possible DDIs for an …

[HTML][HTML] Identifying drug interactions using machine learning

I Demirsoy, A Karaibrahimoglu - Advances in Clinical and …, 2023 - advances.umw.edu.pl
The majority of Americans, accounting for 51% of the population, take 2 or more drugs daily.
Unfortunately, nearly 100,000 people die annually as a result of adverse drug reactions …