Our objective was to determine if β 1-adrenergic receptor (β 1-AR) and β 2-AR gene
polymorphisms influence heart rate (HR), systolic blood pressure (SBP) and diastolic blood …

Background The relevance of the Arg389Gly-and Ser49Gly-β 1-adrenoceptor (AR)
polymorphisms for cardiovascular function and pharmacotherapy is controversial. Methods …

Purpose The aim of this study was to determine an association between the ADRB1 1165C>
G and 145A> G polymorphisms and hemodynamic response [heart rate (HR), systolic (SBP) …

Results Resting heart rate (HR) response to 6 mcg/kg/min dobutamine (ΔHR) was 4.7-fold
larger in Arg389Arg than in Gly389Gly [(mean±SD) 12.95±6.99, 2.75±1.65 bpm …

Background The β 1-adrenoceptor (β 1 AR) mediates cardiostimulatory effects of
catecholamines in the heart. The Arg389Gly polymorphism of the β 1 AR gene has recently …

10q24. The codon 49 polymorphism is located in the receptor's extracellular aminoterminus
domain, and the codon 389 polymorphism is located in the proximal region of the …

Objectives Recently, the Arg389Gly β 1-adrenoceptor (β 1 AR) gene polymorphism has
been detected. The Arg variant exhibited increased responsiveness to agonist-induced …

There is a wide interpersonal difference to dobutamine response during dobutamine stress
echocardiography (DSE). The aim of this study was to determine an association between …

Previous studies have demonstrated that β-adrenergic receptor polymorphisms affect
outcomes in patients with heart failure or after an acute coronary syndrome. Whether β …

Background A common polymorphism of the β1‐adrenergic receptor Arg389Gly markedly
affects function in vitro, but little is known about its in vivo significance. Methods and results …