[HTML][HTML] Clinical and immunological features of severe and moderate coronavirus disease 2019

G Chen, DI Wu, W Guo, Y Cao… - The Journal of …, 2020 - Am Soc Clin Investig
The pandemic coronavirus infectious disease (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In …

[HTML][HTML] SARS-CoV-2: a storm is raging

SF Pedersen, YC Ho - The Journal of clinical investigation, 2020 - Am Soc Clin Investig
The pandemic coronavirus infectious disease (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In …

[HTML][HTML] Clinical and pathological investigation of patients with severe COVID-19

S Li, L Jiang, X Li, F Lin, Y Wang, B Li, T Jiang, W An… - JCI insight, 2020 - ncbi.nlm.nih.gov
BACKGROUND. Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
coronavirus 2 (SARS-CoV-2), has become a pandemic. This study addresses the clinical …

[HTML][HTML] High levels of SARS-CoV-2–specific T cells with restricted functionality in severe courses of COVID-19

D Schub, V Klemis, S Schneitler, J Mihm, PM Lepper… - JCI insight, 2020 - ncbi.nlm.nih.gov
BACKGROUND Patients infected with severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) differ in the severity of disease. We hypothesized that characteristics of SARS …

[HTML][HTML] The laboratory tests and host immunity of COVID-19 patients with different severity of illness

F Wang, H Hou, Y Luo, G Tang, S Wu, M Huang, W Liu… - JCI insight, 2020 - ncbi.nlm.nih.gov
BACKGROUND The coronavirus disease 2019 (COVID-19), infected by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a severe outbreak …

[HTML][HTML] Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis

JG Wilson, LJ Simpson, AM Ferreira, A Rustagi… - JCI insight, 2020 - ncbi.nlm.nih.gov
BACKGROUND Elevated levels of inflammatory cytokines have been associated with poor
outcomes among COVID-19 patients. It is unknown, however, how these levels compare …

[HTML][HTML] Longitudinal COVID-19 profiling associates IL-1RA and IL-10 with disease severity and RANTES with mild disease

Y Zhao, L Qin, P Zhang, K Li, L Liang, J Sun, B Xu… - JCI insight, 2020 - ncbi.nlm.nih.gov
BACKGROUND. Identifying immune correlates of COVID-19 disease severity is an urgent
need for clinical management, vaccine evaluation, and drug development. Here, we present …

[HTML][HTML] IL-6 and CD8+ T cell counts combined are an early predictor of in-hospital mortality of patients with COVID-19

M Luo, J Liu, W Jiang, S Yue, H Liu, S Wei - JCI insight, 2020 - ncbi.nlm.nih.gov
BACKGROUND Fatal cases of COVID-19 are increasing globally. We retrospectively
investigated the potential of immunologic parameters as early predictors of COVID-19 …

[HTML][HTML] Immunologic features in coronavirus disease 2019: functional exhaustion of T cells and cytokine storm

S Mahmoudi, M Rezaei, N Mansouri, M Marjani… - Journal of clinical …, 2020 - Springer
To the Editor: Since the emergence of Coronavirus Disease 2019 (COVID-19) caused by the
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019, the …

[HTML][HTML] A glimpse into the eye of the COVID-19 cytokine storm

K Kuppalli, AL Rasmussen - EBioMedicine, 2020 - thelancet.com
The pathogenesis of pandemic coronavirus disease-2019 (COVID-19) caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) likely depends heavily on …