Abstract Cytochrome P450 2C19 (CYP2C19) is the main (or partial) cause for large
differences in the pharmacokinetics of a number of clinically important drugs. On the basis of …

Background and aims The effect of multidrug resistance transporter gene 1 (MDR1) on the
bioavailability and kinetics of several substrates has not yet been fully elucidated. We …

Abstract Background and Objectives Aripiprazole is an atypical antipsychotic drug that is
metabolized by cytochrome P450 (CYP) 2D6 and CYP3A4, which mainly form its active …

Cytochrome P450 enzymes of subfamily 3A account for as much as 30 and 80% of total
P450 content in liver and intestine, respectively [1, 2]. Their abundant expression, as well as …

Objectives To identify defective alleles of CYP2C19 (CYP2C19* 2 and* 3) in North Indians.
Methods One hundred extensive metabolizers and 21 poor metabolizers of omeprazole …

CYP3A is one of the most important cytochrome P450 isoforms responsible for drug
metabolism by humans because it is the major such enzyme in critical tissues such as the …

Objective The purpose of this study is to evaluate whether a simple formula using limited
blood samples can predict the area under the plasma rabeprazole concentration-time curve …

Background: Omeprazole is mainly metabolized in the liver by CYP2C19, a genetically
determined enzyme, whereas rabeprazole is mainly reduced non‐enzymatically and …

BACKGROUND/AIMS:: The kinetics of omeprazole and itsprimary metabolites 5′-
hydroxyomeprazole and omeprazole sulfone were studied in healthy volunteers to evaluate …

The genetic test is gradually replacing probe drugs as the primary tool for screening
populations for the CYP2C19 polymorphism. A full appreciation for the clinical and …