Uveal melanoma: from lab bench to clinic–new therapeutic advances

AG D'Amico, G Maugeri, V D'Agata… - Frontiers in …, 2023 - frontiersin.org
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, with a
high propensity for metastasis and, historically, a lack of effective treatment options for late …

Uveal melanoma: Progress in molecular biology and therapeutics

Y Li, J Shi, J Yang, S Ge, J Zhang… - … advances in medical …, 2020 - journals.sagepub.com
Uveal melanoma (UM) is the most common intraocular malignancy in adults. So far, no
systemic therapy or standard treatment exists to reduce the risk of metastasis and improve …

Single-cell RNA sequencing reveals key molecular drivers and immune landscape in uveal melanoma: implications for targeted therapy and prognostic modeling

Z Song, W Shao, Z Xiahou, Y Xu, X Zhang - Frontiers in Immunology, 2024 - frontiersin.org
Background Uveal melanoma (UM), arising from melanocytes in the choroid, accounts for
3% to 5% of all melanocytic tumors and over 70% of intraocular malignancies. Despite …

Immunobiology of uveal melanoma: state of the art and therapeutic targets

MS Basile, E Mazzon, P Fagone, A Longo… - Frontiers in …, 2019 - frontiersin.org
Uveal Melanoma (UM) represents the most common primary intraocular malignant tumor in
adults. Although it originates from melanocytes as cutaneous melanoma, it shows significant …

Integrated analysis reveals the dysfunction of signaling pathways in uveal melanoma

S Sun, B Guo, L Xu, R Shi - BMC cancer, 2022 - Springer
Background Uveal melanoma (UM) is the most common primary intraocular malignancy with
a strong tendency to metastasize. The prognosis is poor once metastasis occurs. The …

Biology of advanced uveal melanoma and next steps for clinical therapeutics

JJ Luke, PL Triozzi, KC McKenna… - Pigment cell & …, 2015 - Wiley Online Library
Uveal melanoma is the most common intraocular malignancy although it is a rare subset of
all melanomas. Uveal melanoma has distinct biology relative to cutaneous melanoma, with …

Single-cell and bulk transcriptome analysis reveals tumor cell heterogeneity and underlying molecular program in uveal melanoma

K Li, J Huang, Y Tan, J Sun, M Zhou - Journal of Translational Medicine, 2024 - Springer
Background Uveal melanoma (UM) is a rare and deadly eye cancer with high metastatic
potential. Despite the predominance of malignant cells within the tumor microenvironment …

Transcriptome profiling reveals new insights into the immune microenvironment and upregulation of novel biomarkers in metastatic uveal melanoma

Y Krishna, A Acha-Sagredo, D Sabat-Pośpiech… - Cancers, 2020 - mdpi.com
Simple Summary Uveal melanoma (UM) is a rare aggressive eye cancer. Although
treatment of the eye tumour is successful, about 50% of UM patients develop a relapse of …

[HTML][HTML] Immune profiling of uveal melanoma identifies a potential signature associated with response to immunotherapy

Y Qin, K Bollin, MP De MacEdo… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background To date, no systemic therapy, including immunotherapy, exists to improve
clinical outcomes in metastatic uveal melanoma (UM) patients. To understand the role of …

Clinicopathological and prognostic significance and molecular mechanisms governing uveal melanoma

MY Wu, TT Lai, WT Liao, CJ Li - Therapeutic Advances in …, 2020 - journals.sagepub.com
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults.
Although UM and cutaneous melanoma are derived from melanocytes, UM differs clinically …