N6-methyladenosine methyltransferase WTAP-stabilized FOXD2-AS1 promotes the osteosarcoma progression through m6A/FOXM1 axis

Z Ren, Y Hu, J Sun, Y Kang, G Li, H Zhao - Bioengineered, 2022 - Taylor & Francis
Long noncoding RNAs (lncRNAs) play critical roles in tumor progression regulation,
including osteosarcoma. Evidence indicates that N6-methyladenosine (m6A) modification …

[HTML][HTML] m6A methyltransferase METTL3-mediated lncRNA FOXD2-AS1 promotes the tumorigenesis of cervical cancer

F Ji, Y Lu, S Chen, X Lin, Y Yu, Y Zhu, X Luo - Molecular Therapy …, 2021 - cell.com
Recent studies have indicated that long noncoding RNA (lncRNA) and N 6-
methyladenosine (m 6 A) methylation modification play critical roles in human cancers; …

M6A demethylase FTO-mediated downregulation of DACT1 mRNA stability promotes Wnt signaling to facilitate osteosarcoma progression

D Lv, S Ding, L Zhong, J Tu, H Li, H Yao, Y Zou, Z Zeng… - Oncogene, 2022 - nature.com
Despite advances in clinical diagnosis and treatment, the prognosis of patients with
osteosarcoma (OS) remains poor, and the treatment efficacy has plateaued. Therefore, it is …

METTL3 upregulates COPS5 expression in osteosarcoma in an m6A-related manner to promote osteosarcoma progression

C Zhang, J Wan, Q Liu, F Long, Z Wen, Y Liu - Experimental Cell Research, 2022 - Elsevier
Abstract N6-methyladenosine (m 6 A) is the most abundant and well-studied internal
modification of messenger RNAs (mRNAs). Although m 6 A mRNA modification has been …

[HTML][HTML] HIF-1α induced long noncoding RNA FOXD2-AS1 promotes the osteosarcoma through repressing p21

Z Ren, Y Hu, G Li, Y Kang, Y Liu, H Zhao - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Emerging literature indicates the essential roles of long noncoding RNA (lncRNA) in the
osteosarcoma (OS). However, the regulatory function and mechanism of FOXD2-AS1 in the …

Methylation recognition protein YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) regulates the proliferation, migration and invasion of osteosarcoma by …

K Wei, Y Gao, B Wang, YX Qu - Bioengineered, 2022 - Taylor & Francis
ABSTRACT N6-methyladenosine (m6A) is one of the most significant modifications in
human mRNAs. Emerging evidence indicates that m6A participates in the initiation and …

[HTML][HTML] Downregulation of the long non‑coding RNA FOXD2‑AS1 inhibits cell proliferation, migration and invasion in osteosarcoma

H Zhang, Y Lu, J Wang, T Zhang… - Molecular …, 2019 - spandidos-publications.com
Increasing amounts of long noncoding RNAs (lncRNAs) have been shown to be involved in
the development of cancer. Recently, aberrant expression of the lncRNA forkhead box D2 …

N6-methyladenosine modification-related long non-coding RNAs are potential biomarkers for predicting the prognosis of patients with osteosarcoma

K Yang, F Wang, K Li, G Peng, H Yang… - … in Cancer Research …, 2022 - journals.sagepub.com
Background: The role of N6-methyladenosine (m6A)-related long non-coding RNAs
(lncRNAs) in osteosarcoma (OS) has not been fully studied yet. We aimed to identify m6A …

ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression

X An, W Wu, L Yang, J Dong, B Liu, J Guo, J Chen… - Translational …, 2023 - Elsevier
Abstract Aberrant N6-methyladenosine (m6A) modification of mRNAs contributes
significantly to the epigenetic tumorigenesis, however, its precise role and the key targets in …

[HTML][HTML] Antisense lncRNA FOXF1-AS1 promotes migration and invasion of osteosarcoma cells through the FOXF1/MMP-2/-9 pathway

Z Kun-Peng, Z Chun-Lin… - International Journal of …, 2017 - ncbi.nlm.nih.gov
Osteosarcoma (OS) is the most common primary malignant bone cancer in children and
adolescents. Long non-coding RNAs (lncRNAs) have been shown to play significant role in …