Injury to the peripheral nerves often induces produces spontaneous pain, hyperalgesia
(increased responsiveness to noxious stimuli), and allodynia (painful responses to normally …

The L5 spinal nerve ligation (SNL) is a widely used animal neuropathic pain model. There
are conflicting reports regarding the extent of injury to the L4 dorsal root ganglion (DRG) …

Partial nerve injury often leads to peripheral neuropathic pain (PNP), a major health problem
that lacks effective drug treatment. PNP is characterized by ongoing/spontaneous pain, and …

Neuropathic pain syndromes are clinically characterized by spontaneous pain and evoked
pain (hyperalgesia and allodynia). The optimal treatment approach for neuropathic pain is …

Peripheral neuropathic pain (PNP) is a major health problem for which effective drug
treatment is lacking. Its underlying neuronal mechanisms are still illusive, but pre-clinical …

Satellite glial cells in the dorsal root ganglion (DRG), like the better-studied glia cells in the
spinal cord, react to peripheral nerve injury or inflammation by activation, proliferation, and …

There is a growing body of evidence that cytokines contribute to both induction and
maintenance of neuropathic pain derived from changes in dorsal root ganglia (DRG) …

Tight ligation of the fifth and sixth lumbar segmental nerves in the rat provides a model of
neuropathic pain. We used this model to assess the changes in primary afferent input to the …

Peripheral nerve injuries produce a variety of negative structural and functional changes in
the central terminal sites of damaged axons, as well as the injured primary afferents. Such …

The relationship between pain severity and the extent of injury to a peripheral nerve remains
elusive. In this study, we compared the pain behavior resulting from partial (1/3–1/2 …