Pancreatic cancer is characterised by a prominent desmoplastic/stromal reaction that has
received little attention until recent times. Given that treatments focusing on pancreatic …

One of the characteristic features of the majority of pancreatic ductal adenocarcinomas is an
abundant desmoplastic/stromal reaction. Until recently, this stroma had received little …

Pancreatic cancer is a devastating disease with an unacceptably high mortality to incidence
ratio. Traditional therapeutic approaches such as surgery in combination with chemo-or …

Pancreatic stellate cells (PSCs) are responsible for producing the collagenous stroma in
pancreatic cancer. Findings from the majority of in vitro and in vivo studies to date indicate …

Tumour-stromal interactions have now been acknowledged to play a major role in
pancreatic cancer (PC) progression. The abundant collagenous stroma is produced by a …

Pancreatic ductal adenocarcinoma is a devastating disease, and patient outcomes have not
improved in decades. Treatments that target tumor cells have largely failed. This could be …

Pancreatic cancer—a tumor displaying a particularly abundant stromal reaction—is
notorious for its poor prognosis. Recent studies, via newly developed orthotopic models …

Pancreatic cancer (PC) is the most aggressive type of common cancers, and in 2014, nearly
40000 patients died from the disease in the United States. Pancreatic ductal …

The abundant stromal/desmoplastic reaction, a characteristic feature of a majority of
pancreatic adenocarcinomas (PDAC), has only recently been receiving some attention …

Pancreatic ductal adenocarcinoma is an aggressive and highly lethal disease frequently
characterized by a dense stromal or desmoplastic response. Accumulating evidence exists …