Tocilizumab for the treatment of severe coronavirus disease 2019

R Alattar, TBH Ibrahim, SH Shaar… - Journal of medical …, 2020 - Wiley Online Library
Abstract Tocilizumab, an interleukin‐6 inhibitor, may ameliorate the inflammatory
manifestations associated with severe coronavirus disease 2019 (COVID‐19) and thus …

[HTML][HTML] Tocilizumab treatment for COVID-19 patients: a systematic review and meta-analysis

Q Wei, H Lin, RG Wei, N Chen, F He, DH Zou… - Infectious diseases of …, 2021 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) has killed over 2.5 million
people worldwide, but effective care and therapy have yet to be discovered. We conducted …

Efficacy of tocilizumab in COVID‐19: a systematic review and meta‐analysis

M Aziz, H Haghbin, E Abu Sitta… - Journal of medical …, 2021 - Wiley Online Library
The efficacy of tocilizumab (TOC), monoclonal antibody against interleukin‐6 (IL‐6) receptor,
in patients with coronavirus disease‐2019 (COVID‐19) patients has led to conflicting results …

[HTML][HTML] Effectiveness of tocilizumab in patients with severe or critical lung involvement in COVID-19: a retrospective study

D Chober, B Aksak-Wąs… - Journal of Clinical …, 2022 - mdpi.com
Introduction: Acute lung injury is associated with dysfunctional immune response to SARS-
CoV-2. This leads to CRS, which require immunomodulatory treatments aiming to limit the …

Tocilizumab and COVID-19: a meta-analysis of 2120 patients with severe disease andimplications for clinical trial methodologies

A Sarfraz, Z Sarfraz, M Sarfraz… - Turkish journal of …, 2021 - journals.tubitak.gov.tr
Background/aim: Since the outbreak of the COVID-19, numerous therapies to counteract this
severe disease have emerged. The benefits of Tocilizumab for severely infected COVID-19 …

Outcomes in patients with severe COVID-19 disease treated with tocilizumab: a case–controlled study

G Rojas-Marte, M Khalid, O Mukhtar… - … Journal of Medicine, 2020 - academic.oup.com
Background COVID-19 is an ongoing threat to society. Patients who develop the most
severe forms of the disease have high mortality. The interleukin-6 inhibitor tocilizumab has …

Tocilizumab in the management of COVID-19: a preliminary report

M Li, EJ Yoo, M Baram, M McArthur, C Skeehan… - The American Journal of …, 2021 - Elsevier
Importance Pneumonia due to COVID-19 can lead to respiratory failure and death due to the
development of the acute respiratory distress syndrome. Tocilizumab, a monoclonal …

COVID‐19: Consider IL‐6 receptor antagonist for the therapy of cytokine storm syndrome in SARS‐CoV‐2 infected patients

C Chakraborty, AR Sharma… - Journal of medical …, 2020 - Wiley Online Library
COVID‐19 leads to mortality of several patients and the cytokine storm is reportedly critical
in the patients. To reduce the cytokine storm, we would like to propose the interleukin (IL) 6 …

Tocilizumab in patients hospitalized with COVID-19 pneumonia: systematic review and meta-analysis of randomized controlled trials

S Gupta, RP Padappayil, A Bansal… - Journal of …, 2022 - journals.sagepub.com
Tocilizumab is an interleukin receptor inhibitor that has been used in patients with COVID-19
pneumonia. There are recent randomized controlled trials (RCTs) that evaluated the efficacy …

[HTML][HTML] Effectiveness and safety of tocilizumab for COVID-19: a systematic review and meta-analysis of randomized clinical trials

PRL Almeida, OC Person, MES Puga… - Sao Paulo Medical …, 2022 - SciELO Brasil
ABSTRACT BACKGROUND: Tocilizumab is an anti-human interleukin 6 receptor
monoclonal antibody that has been used to treat coronavirus disease 2019 (COVID-19) …