Background Literature reports that mature microRNA (miRNA) can be methylated at
adenosine, guanosine and cytosine. However, the molecular mechanisms involved in …

Glioblastoma multiforme (GBM) is the most frequently occurring primary malignant brain
tumor; patients with GBM often have a very poor prognosis and differing responses to …

Background Multiple studies proved that miRNAs have a causal role in tumorigenesis. Some
miRNAs are regulated by epigenetic alterations in their promoter regions and can be …

DNA methylation plays a key role in the silencing of numerous cancer-related genes,
thereby affecting a number of vital cellular processes, including the cell cycle checkpoint …

Objectives To evaluate the prognostic values of microRNAs (miRNAs) in glioblastoma, and
to see if there is an association between miRNAs and MGMT promoter methylation status …

MicroRNAs (miRNAs) contribute to the pathogenesis of many forms of cancer, including the
pediatric cancer neuroblastoma, but the underlying mechanisms leading to altered miRNA …

MicroRNAs (miRNAs) are small noncoding RNAs that play fundamental roles in diverse
biological and pathological processes by targeting the expression of specific genes. Here …

ABSTRACT microRNAs (miRNAs) and DNA methylation are the 2 epigenetic modifications
that have emerged in recent years as the most critical players in the regulation of gene …

MicroRNAs (miRNAs) are small RNA molecules that control gene expression by inhibition of
protein translation or by degradation of cognate target mRNAs. Even though strict …

Aberrant methylation has been shown to trigger the inactivation of tumor suppressor genes
during tumorigenesis. MicroRNAs (miRNAs) have been found deregulated in human …