The metabolic activity of the polymorphic CYP2D6 enzyme is dependent on the CYP2D6
genotype; however, the guidelines for translating the genotype into phenotype, which are of …

The cytochrome P450 2D6 (CYP 2D6) gene locus is challenging to accurately genotype due
to numerous single nucleotide variants and complex structural variation. Our goal was to …

Genotyping strategies targeting allelic variants with diminished or no activity to identify poor
metabolizers generally works well in Caucasian (1–3) and Asian (4, 5) populations, but we …

Inferring CYP2D6 phenotype from genotype is increasingly challenging, considering the
growing number of alleles and their range of activity. This complexity poses a challenge in …

Cytochrome P450 2D6 (CYP2D6) is an enzyme of potential importance for the metabolism
of drugs used clinically, and it exhibits genetic polymorphism with interindividual differences …

Unexplained cases of CYP2D6 genotype/phenotype discordance continue to be discovered.
In previous studies, several African Americans with a poor metabolizer phenotype carried …

Abstract Cytochrome P450 2D6 (CYP 2D6) is one of the most widely investigated CYP s
related to genetic polymorphisms and is responsible for one‐quarter of the currently used …

Two novel haplotypes of CYP2D6 were found in Japanese subjects. One haplotype of the
human CYP2D6 gene, newly designated as CYP2D6* 44 allele, had both a novel single …

Polymorphism of the CYP2D6 gene leads to substantial interindividual variability in CYP2D6
enzyme activity. Despite improvements in prediction of CYP2D6 activity based on genotype …

The cytochrome P450 2D6 (CYP2D6) enzyme contributes to the metabolism and/or
bioactivation of approximately 25% of clinically used drugs. The CYP2D6 gene locus is …