During mouse preimplantation embryo development, totipotent blastomeres generate the
first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm. In …

During mammalian preimplantation development, the fertilised egg gives rise to a group of
pluripotent embryonic cells, the epiblast, and to the extraembryonic lineages that support the …

The preimplantation period of mouse early embryonic development is devoted to the
specification of two extraembryonic tissues and their spatial segregation from the pluripotent …

Understanding human embryology has historically relied on comparative approaches using
mammalian model organisms. With the advent of low-input methods to investigate genetic …

The mouse embryo is the canonical model for mammalian preimplantation development.
Recent advances in single cell profiling allow detailed analysis of embryogenesis in other …

Single-cell profiling techniques create opportunities to delineate cell fate progression in
mammalian development. Recent studies have provided transcriptome data from human pre …

The preimplantation mouse embryo is a simple self-contained system, making it an excellent
model to discover how mammalian cells function in real time and in vivo. Work over the last …

Pre-implantation embryo development is an intricate and precisely regulated process
orchestrated by maternally inherited proteins and newly synthesized proteins following …

A critical point in mammalian development is when the early embryo implants into its
mother's uterus. This event has historically been difficult to study due to the fact that it occurs …

Establishing the different lineages of the early mammalian embryo takes place over several
days and several rounds of cell divisions from the fertilized egg. The resulting blastocyst …