Broad sarbecovirus neutralization by a human monoclonal antibody

MA Tortorici, N Czudnochowski, TN Starr, R Marzi… - Nature, 2021 - nature.com
The recent emergence of SARS-CoV-2 variants of concern,,,,,,,,–and the recurrent spillovers
of coronaviruses, into the human population highlight the need for broadly neutralizing …

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry

YJ Park, A De Marco, TN Starr, Z Liu, D Pinto, AC Walls… - Science, 2022 - science.org
Understanding broadly neutralizing sarbecovirus antibody responses is key to developing
countermeasures against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

TN Starr, N Czudnochowski, Z Liu, F Zatta, YJ Park… - Nature, 2021 - nature.com
An ideal therapeutic anti-SARS-CoV-2 antibody would resist viral escape,–, have activity
against diverse sarbecoviruses,,–, and be highly protective through viral neutralization,,–and …

Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies

CA Jette, AA Cohen, PNP Gnanapragasam… - Cell reports, 2021 - cell.com
Many anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) neutralizing
antibodies target the angiotensin-converting enzyme 2 (ACE2) binding site on viral spike …

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

D Pinto, YJ Park, M Beltramello, AC Walls, MA Tortorici… - Nature, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged
coronavirus that is responsible for the current pandemic of coronavirus disease 2019 …

Structural and functional analysis of a potent sarbecovirus neutralizing antibody

D Pinto, YJ Park, M Beltramello, AC Walls, MA Tortorici… - BioRxiv, 2020 - biorxiv.org
SARS-CoV-2 is a newly emerged coronavirus responsible for the current COVID-19
pandemic that has resulted in more than one million infections and 73,000 deaths,. Vaccine …

Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody

CG Rappazzo, LV Tse, CI Kaku, D Wrapp, M Sakharkar… - Science, 2021 - science.org
The recurrent zoonotic spillover of coronaviruses (CoVs) into the human population
underscores the need for broadly active countermeasures. We employed a directed …

A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site

T Onodera, S Kita, Y Adachi, S Moriyama, A Sato… - Immunity, 2021 - cell.com
Potent neutralizing SARS-CoV-2 antibodies often target the spike protein receptor-binding
site (RBS), but the variability of RBS epitopes hampers broad neutralization of multiple …

Pan-sarbecovirus prophylaxis with human anti-ACE2 monoclonal antibodies

F Zhang, J Jenkins, RVH de Carvalho… - Nature …, 2023 - nature.com
Human monoclonal antibodies (mAbs) that target the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) spike protein have been isolated from convalescent …

Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants

T Li, W Xue, Q Zheng, S Song, C Yang, H Xiong… - Nature …, 2021 - nature.com
The emergence of numerous variants of SARS-CoV-2, the causative agent of COVID-19,
has presented new challenges to the global efforts to control the COVID-19 pandemic. Here …