Alteration of dynamic range of modulation to cognitive difficulty has been proposed as a
salient predictor of cognitive aging. Here, we examine in 171 adults (aged 20–94 years) the …

BOLD variability, which measures moment-to-moment fluctuations in brain signal, is
sensitive to age differences in cognitive performance. However, the effect of aging on BOLD …

Older adults tend to over-activate regions throughout frontoparietal cortices and exhibit a
reduced range of functional modulation during WM task performance compared to younger …

While there is extensive literature on the beneficial effects of physical activity on age
differences in cognitive control, limited research exists on comparing the contributions of …

Beta-amyloid (Aβ) positive individuals hyper-activate brain regions compared to those not at-
risk; however, hyperactivation is then thought to diminish as Alzheimer's disease …

Recent evidence indicates that the relationship between increased beta-amyloid (Aβ)
deposition and functional task-activation can be characterized by a non-linear trajectory of …

The ability to flexibly modulate brain activation to increasing cognitive challenge decreases
with aging. This age-related decrease in dynamic range of function of regional gray matter …

It is well documented that older adults recruit additional brain regions compared to those
recruited by younger adults while performing a wide variety of cognitive tasks. However, it is …

Aging is associated with reduced resources needed to perform difficult cognitive tasks, but
the neural underpinnings are not well understood, especially as there is scant evidence …

The time course of neuroanatomical structural and functional measures across the lifespan
is commonly reported in association with aging. Blood oxygen-level dependent signal …