Insulin resistance is a main feature of obesity and type 2 diabetes mellitus (T2DM). Several
mechanisms linking obesity to insulin resistance have been proposed. Adipose tissue …

Apelin is a newly discovered peptide hormone that has recently been linked to insulin
resistance and obesity. Data collected from both the clinical and basic research settings …

Apelin is a peptide known as the ligand of the G-protein-coupled receptor APJ. Several
active apelin forms exist such as apelin-36, apelin-17, apelin-13, and the pyroglutamated …

A wide range of adipokines identified over the past years has allowed considering the white
adipose tissue as a secretory organ closely integrated into overall physiological and …

Apelin, a peptide with several active isoforms ranging from 36 to 12 amino acids and its
receptor APJ, a G-protein-coupled receptor, are widely distributed. However, apelin has …

Adipose tissue (AT) secretes several adipokines that influence insulin sensitivity and
potentially link obesity to insulin resistance. Apelin, a peptide present in different tissues, is …

This paper focuses on the contribution of apelin in obesity associated regulations/
dysregulations. The conclusions are summarized as follows:(i) apelin is produced by fat …

The results presented herein demonstrate that apelin is expressed and secreted by both
human and mouse adipocytes. Apelin mRNA levels in isolated adipocytes are close to other …

The recently discovered peptide apelin is known to be involved in the maintenance of insulin
sensitivity. However, questions persist regarding its precise role in the chronic setting …

Apelin is a peptide present in different cell types and secreted by adipocytes in humans and
rodents. Apelin exerts its effects through a G-protein-coupled receptor called APJ. During the …