Machine-learning-based clinical biomarker using cell-free DNA for hepatocellular carcinoma (HCC)

T Lee, PA Rawding, J Bu, S Hyun, W Rou, H Jeon… - Cancers, 2022 - mdpi.com
Simple Summary Circulating cell-free DNA (cfDNA) has attracted a great deal of scientific
interest as a predictive biomarker for the diagnosis and prognosis of hepatocellular …

Advances in biomarker discovery using circulating cell‐free DNA for early detection of hepatocellular carcinoma

M Liu, Z Zhang, W Zhang, SM Liu - WIREs mechanisms of …, 2023 - Wiley Online Library
The past several decades have witnessed unprecedented progress in basic and clinical
cancer research, and our understanding of the molecular mechanisms and pathogenesis of …

Clinical application value of circulating cell-free DNA in hepatocellular carcinoma

Y Zhang, Z Liu, K Ji, X Li, C Wang, Z Ren… - Frontiers in Molecular …, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and a
leading cause of cancer-related deaths. Due to late diagnosis, early intrahepatic metastasis …

Bioinformatics analysis methods for cell-free DNA

Y Chen, Y Gong, L Dou, X Zhou, Y Zhang - Computers in Biology and …, 2022 - Elsevier
As a kind of novel non-invasive marker for molecular detection, cell-free DNA (cfDNA) has
potential value for the early diagnosis of diseases, prognosis assessment, and efficacy …

Cell-free DNA analysis by whole-exome sequencing for hepatocellular carcinoma: a pilot study in Thailand

P Kunadirek, N Chuaypen, P Jenjaroenpun… - Cancers, 2021 - mdpi.com
Simple Summary Liquid biopsy for cell-free DNA (cfDNA) is a non-invasive technique to
characterize the genetic profile of a tumor. Despite being a valuable tool, there is no …

Circulating-free DNA analysis in hepatocellular carcinoma: a promising strategy to improve patients' management and therapy outcomes

S Mezzalira, E De Mattia, M Guardascione… - International Journal of …, 2019 - mdpi.com
Hepatocellular carcinoma (HCC) is the sixth most common malignancy worldwide,
representing the third leading cause of cancer-related deaths. HCC genetic characterization …

Circulating cell-free DNA in hepatocellular carcinoma: current insights and outlook

CKY Ng, GG Di Costanzo, LM Terracciano… - Frontiers in …, 2018 - frontiersin.org
Over the past decade, the advancements in massively parallel sequencing have provided a
new paradigm in biomedical research to uncover the genetic basis of human diseases …

[HTML][HTML] Detection and monitoring of HBV-related hepatocellular carcinoma from plasma cfDNA fragmentation profiles

X Sun, W Feng, P Cui, R Ruan, W Ma, Z Han, J Sun… - Genomics, 2022 - Elsevier
Most hepatocellular carcinomas (HCCs) are associated with hepatitis B virus infection (HBV)
in China. Early detection of HCC can significantly improve prognosis but is not yet fully …

Detection and characterization of pancreatic and biliary tract cancers using cell-free DNA fragmentomics

X Shi, S Guo, Q Duan, W Zhang, S Gao, W Jing… - Journal of Experimental …, 2024 - Springer
Background Plasma cell-free DNA (cfDNA) fragmentomics has demonstrated significant
differentiation power between cancer patients and healthy individuals, but little is known in …

Enhanced detection of cell-free DNA (cfDNA) enables its use as a reliable biomarker for diagnosis and prognosis of gastric cancer

J Bu, TH Lee, W Jeong, MJ Poellmann, K Mudd… - PLoS …, 2020 - journals.plos.org
Although circulating cell-free DNA (cfDNA) is a promising biomarker for the diagnosis and
prognosis of various tumors, clinical correlation of cfDNA with gastric cancer has not been …