[HTML][HTML] Exploiting the molecular basis of age and gender differences in outcomes of SARS-CoV-2 infections

D Mercatelli, E Pedace, P Veltri, FM Giorgi… - Computational and …, 2021 - Elsevier
Motivation: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
(coronavirus disease, 2019; COVID-19) is associated with adverse outcomes in patients. It …

[HTML][HTML] COVID-19 in elderly adults: clinical features, molecular mechanisms, and proposed strategies

Y Yang, Y Zhao, F Zhang, L Zhang, L Li - Aging and disease, 2020 - ncbi.nlm.nih.gov
Abstract Coronavirus disease 2019 (COVID-19) is causing problems worldwide. Most
people are susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Molecular features similarities between SARS-CoV-2, SARS, MERS and key human genes could favour the viral infections and trigger collateral effects

LL Maldonado, AM Bertelli, L Kamenetzky - Scientific Reports, 2021 - nature.com
In December 2019, rising pneumonia cases caused by a novel β-coronavirus (SARS-CoV-2)
occurred in Wuhan, China, which has rapidly spread worldwide, causing thousands of …

Bioinformatics and system biology approach to identify the influences of COVID-19 on cardiovascular and hypertensive comorbidities

A Nashiry, S Sarmin Sumi, S Islam… - Briefings in …, 2021 - academic.oup.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected individuals that
have hypertension or cardiovascular comorbidities have an elevated risk of serious …

The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2

RD Chow, M Majety, S Chen - Nature Communications, 2021 - nature.com
Age is a major risk factor for severe coronavirus disease-2019 (COVID-19). Here, we
interrogate the transcriptional features and cellular landscape of the aging human lung. By …

Identification of Comorbidities, Genomic Associations, and Molecular Mechanisms for COVID‐19 Using Bioinformatics Approaches

SBS Omit, S Akhter, HK Rana… - BioMed Research …, 2023 - Wiley Online Library
Several studies have been done to identify comorbidities of COVID‐19. In this work, we
developed an analytical bioinformatics framework to reveal COVID‐19 comorbidities, their …

[HTML][HTML] Applying the digital data and the bioinformatics tools in SARS-CoV-2 research

M Tan, J Xia, H Luo, G Meng, Z Zhu - Computational and Structural …, 2023 - Elsevier
Bioinformatics has been playing a crucial role in the scientific progress to fight against the
pandemic of the coronavirus disease 2019 (COVID-19) caused by the severe acute …

[HTML][HTML] Transcriptomic signatures and repurposing drugs for COVID-19 patients: findings of bioinformatics analyses

G Li, S Ruan, X Zhao, Q Liu, Y Dou, F Mao - Computational and Structural …, 2021 - Elsevier
The novel coronavirus SARS-CoV-2 is damaging the world's social and economic fabrics
seriously. Effective drugs are urgently needed to decrease the high mortality rate of COVID …

Computational identification of host genomic biomarkers highlighting their functions, pathways and regulators that influence SARS-CoV-2 infections and drug …

MP Mosharaf, MS Reza, MK Kibria, FF Ahmed… - Scientific reports, 2022 - nature.com
The pandemic threat of COVID-19 has severely destroyed human life as well as the
economy around the world. Although, the vaccination has reduced the outspread, but …

Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesis

MG Ferrarini, A Lal, R Rebollo, AJ Gruber… - Communications …, 2021 - nature.com
The novel betacoronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
caused a worldwide pandemic (COVID-19) after emerging in Wuhan, China. Here we …