SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule

A Werion, L Belkhir, M Perrot, G Schmit, S Aydin… - Kidney international, 2020 - Elsevier
Coronavirus disease 2019 (COVID-19) is commonly associated with kidney damage, and
the angiotensin converting enzyme 2 (ACE2) receptor for SARS-CoV-2 is highly expressed …

[HTML][HTML] Ultrastructural evidence for direct renal infection with SARS-CoV-2

EA Farkash, AM Wilson, JM Jentzen - Journal of the American …, 2020 - journals.lww.com
Background A significant fraction of patients with coronavirus disease 2019 (COVID-19)
display abnormalities in renal function. Retrospective studies of patients hospitalized with …

[HTML][HTML] SARS-CoV-2 causes acute kidney injury by directly infecting renal tubules

Z Chen, J Hu, L Liu, R Chen, M Wang… - Frontiers in cell and …, 2021 - frontiersin.org
Acute kidney injury (AKI) is one of the most prevalent complications among hospitalized
coronavirus disease 2019 (COVID-19) patients. Here, we aim to investigate the causes, risk …

COVID-19 Survival and its impact on chronic kidney disease

JD Long, IAN Strohbehn, R Sawtell… - Translational …, 2022 - Elsevier
Up to 87% of patients hospitalized with coronavirus disease 2019 (COVID-19) experience
chronic sequelae following infection. The long-term impact of COVID-19 infection on kidney …

Is the kidney a target of SARS-CoV-2?

MA Martinez-Rojas, O Vega-Vega… - American Journal of …, 2020 - journals.physiology.org
The new disease produced by severe acute respiratory syndrome-coronavirus 2 (SARS-
CoV-2) represents a major pandemic event nowadays. Since its origin in China in …

[HTML][HTML] Renal manifestations of Covid-19: physiology and pathophysiology

Z Armaly, S Kinaneh, K Skorecki - Journal of clinical medicine, 2021 - mdpi.com
Corona virus disease 2019 (COVID-19) imposes a serious public health pandemic affecting
the whole world, as it is spreading exponentially. Besides its high infectivity, SARS-CoV-2 …

[HTML][HTML] Long COVID and kidney disease

S Yende, CR Parikh - Nature Reviews Nephrology, 2021 - nature.com
Kidney involvement is common in patients with acute SARS-CoV-2 infection, and subclinical
inflammation and injury may persist for many months, resulting in a progressive decline in …

[HTML][HTML] COVID-19 and the kidney: time to take a closer look

V Liakopoulos, S Roumeliotis, S Papachristou… - … Urology and Nephrology, 2022 - Springer
Abstract Although coronavirus disease (COVID-19) is primarily a respiratory disease, the
kidney may be among the target organs of infection with severe acute respiratory syndrome …

[HTML][HTML] SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

J Jansen, KC Reimer, JS Nagai, FS Varghese… - Cell stem cell, 2022 - cell.com
Kidney failure is frequently observed during and after COVID-19, but it remains elusive
whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects …

[HTML][HTML] Kidney involvement in COVID-19 and rationale for extracorporeal therapies

C Ronco, T Reis - Nature Reviews Nephrology, 2020 - nature.com
The prevalence of direct kidney involvement in novel coronavirus disease (COVID-19) is
low, but such involvement is a marker of multiple organ dysfunction and severe disease …