Eighteen analogues of an active natural chalcone were synthesized using xanthoxyline and
some derivatives, and these analogues were tested for selective activity against both …

The in vitro screening of 43 polysubstituted chalcones against Leishmania amazonensis
axenic amastigotes, led to the evaluation of 9 of them in a macrophage-infected model with …

Leishmaniases are endemic diseases in tropical and sub-tropical regions of the world and
are considered by the World Health Organization (WHO) to be among the six most important …

Ten chalcones were synthesized and tested as potential leishmanicidal and trypanocidal
agents. All tested compounds caused concentration-dependent inhibition of the in vitro …

A variety of chalcones have been shown to exhibit activity against Leishmania parasites. In
contrast to synthetic or semisynthetic chalcones, only a few plant‐derived compounds have …

The treatment of American cutaneous leishmaniasis (ACL) is based on a small group of
compounds that were developed decades ago, all of which are highly toxic and have a high …

Two types of regioisomeric chromene‐based chalcones namely, 1‐(6‐methoxy‐2H‐
chromen‐3‐yl)‐3‐phenylpropen‐1‐ones and 3‐(6‐methoxy‐2H‐chromen‐3‐yl)‐1 …

All currently used first-line and second-line drugs for the treatment of leishmaniasis exhibit
several drawbacks including toxicity, high costs and route of administration. Furthermore …

Despite clinical importance of leishmaniasis, an infectious disease that affects 12 thousand
million people in 88 countries, the treatment is still unsatisfactory due to its limited efficacy …

Several new chalcone analogues were synthesized and evaluated as inhibitors of malaria
parasite. Inhibitory activity was determined in vitro against a chloroquine-sensitive …