Type 2 diabetes (T2D) had long been referred to as the" geneticist's nightmare." Genome-
wide association studies have fully confirmed the polygenic nature of T2D, demonstrating …

Improved molecular understanding of the pathogenesis of type 2 diabetes is essential if
current therapeutic and preventative options are to be extended. To identify diabetes …

Type 1 Diabetes (T1D) is a chronic multifactorial disease with a strong genetic component,
which, through interactions with specific environmental factors, triggers disease onset. T1D …

OBJECTIVE Type 1 diabetes arises from the actions of multiple genetic and environmental
risk factors. Considerable success at identifying common genetic variants that contribute to …

Our understanding of the genetics of type 2 diabetes mellitus (T2DM) has changed, in part
owing to implementation of genome-wide association studies as a method for unraveling the …

Understanding the physiological mechanisms by which common variants predispose to type
2 diabetes requires large studies with detailed measures of insulin secretion and sensitivity …

The molecular mechanisms involved in the development of type 2 diabetes are poorly
understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 …

Performing genetic studies in multiple human populations can identify disease risk alleles
that are common in one population but rare in others, with the potential to illuminate …

To understand the genetics of type 2 diabetes in people of Japanese ancestry, we
conducted A meta-analysis of four genome-wide association studies (GWAS; 36,614 cases …

Aims/hypothesis Recent genome-wide association studies performed in selected patients
and control participants have provided strong support for several new type 2 diabetes …