Structural and functional brain connectivity, synaptic activity, and information processing
require highly coordinated signal transduction between different cell types within the …

Background Accumulation and deposition of β-amyloid peptides (Aβ) in the brain is a central
event in the pathogenesis of Alzheimer's disease (AD). Besides the parenchymal pathology …

Alzheimer's disease (AD) is a neurodegenerative disorder associated with continual decline
in cognition and ability to perform routine functions such as remembering familiar places or …

In autoimmune neurologic disorders, the blood–brain barrier (BBB) plays a central role in
immunopathogenesis, since this vascular interface is an entry path for cells and effector …

The symptoms of Alzheimer disease reflect a loss of neural circuit integrity in the brain, but
neurons do not work in isolation. Emerging evidence suggests that the intricate balance of …

Alzheimer's disease (AD) is the most common cause of dementia and is characterized by
progressive neurodegeneration and cognitive decline. Understanding the pathophysiology …

Alzheimer disease (AD) is marked by profound neurodegeneration, neuroinflammation, and
cognitive decline. Pathologically, AD is characterized by the accumulation of extracellular …

An intact blood-brain barrier (BBB) limits entry of proinflammatory and neurotoxic blood-
derived factors into the brain parenchyma. The BBB is damaged in Alzheimer's disease …

Impairment of the blood brain barrier (BBB) in human brain ageing and its relationship to
Alzheimer-type pathology remains poorly defined. We have investigated the BBB in …

Neurological degeneration after neuroinflammation, such as that resulting from Alzheimer's
disease (AD), stroke, multiple sclerosis (MS), and post-traumatic brain injury (TBI), is …