Cytokines, essential mediators of inflammatory and immune responses, play an important
role in the pathophysiological processes associated with neuropathic pain following …

Neuroimmune–glia interactions have been implicated in the development of neuropathic
pain. Interleukin-27 (IL-27) is a cytokine that presents regulatory activity in inflammatory …

Interleukin (IL)-17A, a recently described novel T cell cytokine, orchestrates inflammation in
a variety of immune-mediated diseases. In the present investigation, we analyzed the …

Abstract Interleukin-17A (IL-17A) is considered an important pro-inflammatory cytokine but
its importance in joint diseases such as rheumatoid arthritis (RA) is unclear. It has also been …

Central neuroinflammation is important in the pathophysiological processes of neuropathic
pain following peripheral nerve injury. Recently, interleukin-17 (IL-17) has been detected in …

IL-17 is up-regulated in spinal astrocytes during inflammation and facilitates behavioral
hyperalgesia through promoting phosphorylation of NR1, the essential subunit of the N …

Interleukin (IL)-18 is an important regulator of innate and acquired immune responses. Here
we show that both the IL-18 and IL-18 receptor (IL-18R), which are induced in spinal dorsal …

Chronic pain remains to be a clinical challenge and is recognized as a major health problem
with varying impacts on quality of life. Currently, the first-line therapy for chronic pain is …

The release of inflammatory mediators from immune and glial cells either in the peripheral or
CNS may have an important role in the development of physiopathological processes such …

Interleukin-17 (IL-17) and tumour necrosis factor-α (TNF) are critical in the pathogenesis of
arthritis but their relationship during inflammatory pain has received limited attention. We …