1 Peto R, Boreham J, Clarke M, Davies C, Beral V. UK and USA breast cancer deaths down
25% in year 2000 at ages 20–69 years. Lancet 2000; 355: 1822. 2 Veronesi U …

Mammographic screening, modem surgical techniques, radiotherapy, and adjuvant drug
treatment have had little impact on mortality from breast cancer. This stark reality has …

Breast cancer: cause and prevention Page 1 883 Breast cancer: cause and prevention
Introduction Breast cancer is the second most common cancer among women in the world; in …

Breast cancer is the commonest cause of cancer death in women worldwide. Rates vary
about five-fold around the world, but they are increasing in regions that until recently had low …

The case for treating women at high risk of breast cancer with the anti-oestrogen tamoxifen
is presented. This is a logical extension of a screening programme and is scientifically …

Discusses the National Cancer Institute's (NCI) launching of a large breast cancer
prevention trial in 1992. Number of women recruited for the study that will compare …

Background Tamoxifen, a drug with antioestrogenic effects, is predicted to prevent the
occurrence of breast cancer. We have undertaken a trial of tamoxifen in healthy women who …

Breast cancer is the most common cancer in women worldwide, comprising 23% of all
cancers, with more than 1 million new cases per year. 1 The main risk factors are related to …

Sir—During the 1980s there was increasing use in the UK and the USA of hormonal and
cytotoxic treatments for early breast cancer (and for advanced disease), and meta-analyses …

Placebo Tamoxifen BCPT 13 388 46 858 6· 6 3· 6 Powles 2471 12 355 5· 0 4· 7 Veronesi
5408 20 731 2· 3 2· 1 since few women in the trial completed 8 years of tamoxifen (6· 3%) …