Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome

LYC Chen, RL Hoiland, S Stukas… - European …, 2020 - Eur Respiratory Soc
The concept of coronavirus disease 2019 (COVID-19)-related cytokine storm syndrome
(COVID-CSS) emerged early in the severe acute respiratory syndrome coronavirus 2 (SARS …

Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients

Y Zhou, B Fu, X Zheng, D Wang, C Zhao… - National Science …, 2020 - academic.oup.com
Pathogenic human coronavirus infections, such as severe acute respiratory syndrome CoV
(SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV), cause high morbidity …

[HTML][HTML] Immunological and inflammatory profiles in mild and severe cases of COVID-19

JW Song, C Zhang, X Fan, FP Meng, Z Xu, P Xia… - Nature …, 2020 - nature.com
Abstract COVID-19 is associated with 5.1% mortality. Although the virological,
epidemiological, clinical, and management outcome features of COVID-19 patients have …

[HTML][HTML] Histopathological findings and viral tropism in UK patients with severe fatal COVID-19: a post-mortem study

B Hanley, KN Naresh, C Roufosse… - The Lancet …, 2020 - thelancet.com
Background Severe COVID-19 has a high mortality rate. Comprehensive pathological
descriptions of COVID-19 are scarce and limited in scope. We aimed to describe the …

Cytokine profiles in the detection of severe lung involvement in hospitalized patients with COVID-19: The IL-8/IL-32 axis

L Bergantini, M d'Alessandro, P Cameli, A Otranto… - Cytokine, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) is an infectious respiratory disorder caused
by a new coronavirus called SARS-CoV-2. The pathophysiology of severe COVID-19 is …

[HTML][HTML] Circulating levels of interleukin-6 and interleukin-10, but not tumor necrosis factor-alpha, as potential biomarkers of severity and mortality for COVID-19 …

W Udomsinprasert, J Jittikoon… - Journal of clinical …, 2021 - Springer
Purpose Cytokine storm, an uncontrolled overproduction of inflammatory cytokines
contributing to an aberrant systemic inflammatory response, is a major pathological feature …

Severe acute respiratory syndrome coronavirus 2 pandemic: review of the literature and proposal for safe autopsy practice

I Aquila, MA Sacco, L Abenavoli… - … of Pathology & …, 2020 - meridian.allenpress.com
Context.—The novel coronavirus disease 2019 (COVID-19) pandemic is significantly
changing methodologic approaches in all branches of the health system. From a forensic …

Retrospective analysis of clinical features in 101 death cases with COVID-19

H Fan, L Zhang, B Huang, M Zhu, Y Zhou, H Zhang… - MedRxiv, 2020 - medrxiv.org
Summary Background In December 2019, viral pneumonia outbreaks caused by the novel
coronavirus occurred in Wuhan, China, and spread rapidly worldwide, the illness progress …

[HTML][HTML] Covid-19 deaths: are we sure it is pneumonia? Please, autopsy, autopsy, autopsy!

C Pomara, G Li Volti, F Cappello - Journal of clinical medicine, 2020 - mdpi.com
The current outbreak of COVID-19 severe respiratory disease, which started in Wuhan,
China, is an ongoing challenge, and a major threat to public health that requires …

Endothelial dysfunction and thrombosis in patients with COVID-19—brief report

S Nagashima, MC Mendes… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: Alveolar-capillary endothelial cells can be activated by severe acute respiratory
syndrome coronavirus 2 infection leading to cytokine release. This could trigger endothelial …