Results Plasmid-host coevolution improves plasmid persistence. We first tested the
hypothesis that the self-transmissible plasmid pBP136Km can become more persistent in …

Conjugative plasmids play a vital role in bacterial evolution and promote the spread of
antibiotic resistance. They usually cause fitness costs that diminish the growth rates of the …

Conjugative plasmids are mobile elements that spread horizontally between bacterial hosts
and often confer adaptive phenotypes, including antimicrobial resistance (AMR). Theory …

Antimicrobial resistance (AMR) is a major threat to public health, which, left unchecked, will
have severe impacts on mortality. Plasmids are extrachromosomal DNA elements often …

Promiscuous plasmids replicate in a wide range of bacteria and therefore play a key role in
the dissemination of various host-beneficial traits, including antibiotic resistance. Despite the …

Conjugative plasmids can confer antimicrobial resistance (AMR) to their host bacterium. The
plasmids disperse even between distantly related host species, rescuing the host from …

Horizontal gene transfer mediated by broad-host-range plasmids is an important mechanism
of antibiotic resistance spread. While not all bacteria maintain plasmids equally well …

Rising rates of antimicrobial resistance (AMR) are a threat to global health. The spread of
AMR genes in bacteria is driven to a large extent by the action of plasmids (1). Plasmids are …

The global dissemination of plasmids encoding antibiotic resistance represents an urgent
issue for human health and society. While the fitness costs for host cells associated with …

Multidrug resistant bacterial pathogens have become a serious global human health threat,
and conjugative plasmids are important drivers of the rapid spread of resistance to last …