A number of rat neuropathy models have been developed to simulate human neuropathic
pain conditions, such as spontaneous pain, hyperalgesia, and allodynia. In the present …

To elucidate the role of the degeneration of motor and sensory fibers in neuropathic pain, we
examined the pain-related behaviors and the changes of brain-derived neurotrophic factor …

Chronic constriction injury of the sciatic nerve and lumbar L5 and L6 spinal nerve ligation
provide animal models for pain syndromes accompanying peripheral nerve injury and …

Peripheral nerve injury results in plastic changes in the dorsal root ganglia and spinal cord,
and is often complicated with neuropathic pain. The mechanisms underlying these changes …

We have previously demonstrated that profound and persistent neuropathic pain as
displayed by mechanical and cold allodynia and thermal hyperalgesia can be produced by …

Selective motor nerve injury by lumbar 5 ventral root transection (L5 VRT) induces
neuropathic pain, but the underlying mechanisms remain unknown. Previously, increased …

Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are two major
members of the neurotrophin family. Using immunohistochemistry and in situ hybridization …

A variety of molecules released by inflammatory reactions in the dorsal root and dorsal root
ganglion (DRG) may play important roles in the pathology of neuronal abnormalities in …

To reveal roles of neurotrophic factors in plastic changes of the primary afferent neurons
following nerve injury, we investigated expression of glial cell line-derived neurotrophic …

In the present study, we evaluated changes in brain-derived neurotrophic factor (BDNF)
immunoreactivity in the rat lumbar (L) 5 dorsal root ganglion (DRG) and areas where …