BACKGROUND An increase in thyroid cancers, predominantly papillary thyroid carcinoma
(PTC), has been recently reported in children. METHODS The histopathology of 28 …

Background: Pediatric papillary thyroid carcinoma (PTC) is a rare malignancy, but with
increasing incidence. Pediatric PTCs have distinct clinical and pathological features and …

BACKGROUND Molecular characterization in pediatric papillary thyroid cancer (PTC),
distinct from adult PTC, is important for developing molecularly targeted therapies for …

Simple Summary NTRK fusion genes are important but not well studied molecular markers
in thyroid cancer. Their identification could help improve diagnosis and prognosis, and …

Objective PTC-specific analysis identified novel fusions involving RET, BRAF, NTRK1,
NTRK3, AGK and ALK genes in adults and pediatric PTCs. Although many novel fusions are …

PURPOSE In 2014, data from a comprehensive multiplatform analysis of 496 adult papillary
thyroid cancer samples reported by The Cancer Genome Atlas project suggested that …

PURPOSE Neurotrophic tyrosine receptor kinase (NTRK) fusions have been described as
oncogenic drivers in a variety of tumors. However, little is known about the overall frequency …

Background: Previous studies reported significant differences in the clinical presentation
and outcomes of papillary thyroid carcinoma (PTC) in pediatric patients compared with …

Background. The expression of RET/PTC chimeras was demonstrated in 10% to 20% of
sporadic papillary thyroid carcinomas (PTCs), whereas rearrangements ofNTRK 1 were …

The papillary carcinoma family (PCF) of thyroid tumors includes a wide variety of neoplastic
entities regarded as well-differentiated, poorly differentiated, and undifferentiated papillary …