Adjuvant treatment with ursodeoxycholic acid reduces acute rejection after liver transplantation

S Friman, H Persson, T Schersten, J Svanvik… - … Official Journal of the …, 1992 - Springer
Acute rejection, occurring with a reported frequency of 50–70%, is still a dominating problem
after liver transplantation. Medication with ursodeoxycholic acid (UDCA) has beneficial …

Adjuvant treatment with ursodeoxycholic acid prevents acute rejection in rats receiving heart allografts

M Olausson, L Mjörnstedt, L Wramner… - … Official Journal of the …, 1992 - Springer
Adjuvant treatment with ursodeoxycholic acid (UDCA) for liver-transplant recipients has
been reported to reduce the frequency of acute rejection episodes. To explore this effect …

Failure of ursodeoxycholic acid to prevent acute cellular rejection after liver transplantation

GP Pageaux, P Blanc, PF Perrigault, F Navarro… - Journal of …, 1995 - Elsevier
Background/Aims: Acute rejection is still a major problem after liver transplantation.
Ursodeoxycholic acid has beneficial effects in cholestasis by reducing the expression of …

Evidence that ursodeoxycholic acid prevents steroid-resistant rejection in adult liver transplantation.

PA Clavien, AI Sharara, CA Camargo Jr… - Clinical …, 1996 - europepmc.org
Steroid-resistant rejection continues to be a serious problem in liver transplantation. Since
ursodeoxycholic acid (UDCA) is beneficial in several cholestatic disorders and possesses in …

[PDF][PDF] A randomized clinical trial of ursodeoxycholic acid as adjuvant treatment to prevent liver transplant rejection

D Barnes, D Talenti, G Cammell, M Goormastic… - …, 1997 - Wiley Online Library
Acute rejection following orthotopic liver transplantation is a common problem despite
current immunosuppressive regimens. Ursodeoxycholic acid (UDCA) has been shown in …

A possible role of ursodeoxycholic acid in liver transplantation

S Friman, J Svanvik - Scandinavian Journal of Gastroenterology, 1994 - Taylor & Francis
There are many different causes of graft dysfunction and cholestasis after liver
transplantation. These include non-primary function, preservation and reperfusion injury …

A prospective, randomized, double-blind trial evaluating the efficacy of ursodeoxycholic acid in prevention of liver transplant rejection

JF Fleckenstein, M Paredes, PJ Thuluvath - Liver Transplantation, 1998 - journals.lww.com
Acute cellular rejection (ACR) after orthotopic liver transplantation occurs in 50% to 80% of
patients despite the recent advances in immunosuppressive therapy. Adjuvant use of …

THE NORDIC MULTICENTER DOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL OF PROPHYLACTIC URSODEOXYCHOLIC ACID IN LIVER TRANSPLANT …

S Keiding, K Höckerstedt, K Bjøro, S Bondesen… - …, 1997 - journals.lww.com
Background. Prophylactic treatment with ursodeoxycholic acid (UDCA) has been reported to
reduce the incidence of acute rejection after liver transplantation compared with historical …

Adjuvant treatment with ursodeoxycholic acid may reduce the incidence of acute cardiac allograft rejection.

S Bährle, G Szabo, A Stiehl, L Theilmann… - The Journal of heart …, 1998 - europepmc.org
Background The nontoxic bile acid, ursodeoxycholic acid (UDCA), is an effective drug for the
treatment of different cholestatic conditions. Furthermore, an immunomodulatory capacity of …

Effect of pretransplantation ursodeoxycholic acid therapy on the outcome of liver transplantation in patients with primary biliary cirrhosis

JE Heathcote, J Stone, K Cauch-Dudek… - Liver …, 1999 - journals.lww.com
As ursodeoxycholic acid (UDCA) delays the need for transplantation, this could result in
patients with more comorbid disease, therefore more likely to have a worse outcome …