Toll-like receptors (TLR) are crucial components in the initiation of innate immune responses
to a variety of pathogens, triggering the production of pro-inflammatory cytokines and type I …

Background: Recently, loss-of-function variants in TLR7 were identified in two families in
which COVID-19 segregates like an X-linked recessive disorder environmentally …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the recent
pandemic of coronavirus disease-19 (COVID-19) has a long, positive-sense, non …

Background Toll-like receptors are implicated in the pathophysiology of the severe acute
respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory disease …

Introduction Loss-of-function TLR7 variants have been recently reported in a small number
of males to underlie strong predisposition to severe COVID-19. We aimed to determine the …

The role of innate immunity in COVID-19 is not completely understood. Therefore, this study
explored the impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) …

Abstract Toll-like receptor 3 (TLR3) and TLR7 genes are involved in the host immune
response against viral infections including SARS-COV-2. This study aimed to investigate the …

Innate and acquired immunity responses are crucial for viral infection elimination. However,
genetic variations in coding genes may exacerbate the inflammation or initiate devastating …

Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) is the causative
agent of Corona Virus Disease 2019 (COVID-19). Lower production of type I and III …

Tweetable abstract Toll-like receptor 4, an innate immune sensor, is one of the key 'fate-
deciding'regulators of immunity as well as COVID-19 immunopathogenesis. Suitable …