An Aspergillus parasiticus gene, designated apa-2, was identified as a regulatory gene
associated with aflatoxin biosynthesis. The apa-2 gene was cloned on the basis of …

Aflatoxins are extremely potent carcinogens produced by Aspergillus flavus and Aspergillus
parasiticus. Cloning of genes in the aflatoxin pathway provides a specific approach to …

The genes encoding the aflatoxin biosynthetic pathway enzymes have been localized as a
cluster to a 75-kb DNA fragment. The enzymatic functions of the products of most of the …

Two genes involved in aflatoxin B1 (AFB1) biosynthesis in Aspergillus parasiticus, nor-1 and
ver-1, were localized to a 35-kb region on one A. parasiticus chromosome and to the …

Aspergillus flavus mutant strain 649, which has a genomic DNA deletion of at least 120 kb
covering the aflatoxin biosynthesis cluster, was transformed with a series of overlapping …

Aflatoxins belong to a family of decaketides that are produced as secondary metabolites by
Aspergillus flavus and A. parasiticus. The aflatoxin biosynthetic pathway involves several …

The presence, but not expression, of homologs of three structural genes and a regulatory
gene necessary for aflatoxin biosynthesis in Aspergillus parasiticus and A. flavus was shown …

The Aspergillus parasiticus aflJ gene, which is located in the aflatoxin biosynthetic gene
cluster and is transcribed divergently from the aflatoxin pathway regulatory gene aflR …

Aflatoxins are toxic and carcinogenic secondary metabolites produced by the fungi
Aspergillus flavus and A. parasiticus. Aflatoxins are synthesized by condensation of acetate …

Among the enzymatic steps in the aflatoxin biosynthetic pathway, the conversion of O-
methylsterigmatocystin to aflatoxin has been proposed to be catalyzed by an …