Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed
cholesterol balance underlies not only cardiovascular disease but also an increasing …

Cholesterol plays several structural and metabolic roles that are vital for human biology. It
spreads along the entire plasma membrane of the cell, modulating fluidity and concentrating …

Cholesterol plays a key role in many cellular processes, and is generated by cells through
de novo biosynthesis or acquired from exogenous sources through the uptake of low-density …

Cholesterol has evolved to fulfill sophisticated biophysical, cell signaling and endocrine
requirements of animal systems. At a cellular level, cholesterol is found in membranes …

Maintaining cholesterol and triglyceride (TG) levels within healthy limits is critical for
decreasing the risk of heart disease. Dyslipidemia refers to the abnormal levels of lipids in …

Cholesterol homeostasis is a highly regulated process in human body because of its several
functions underlying the biology of cell membranes, the synthesis of all steroid hormones …

Cholesterol, the most important sterol in mammals, helps maintain plasma membrane fluidity
and is a precursor of bile acids, oxysterols, and steroid hormones. Cholesterol in the body is …

Objective: Cholesterol is an important molecule in humans and both its excess and its
deficiency cause disease. Most clinicians appreciate its role in stabilizing cellular plasma …

Cholesterol is an essential molecule that exerts pleiotropic actions. Although its presence is
vital to the cell, its excess can be harmful and, therefore, sustaining cholesterol homeostasis …