BACKGROUND: Although the mammalian central nervous system contains numerous matrix
metalloproteinases (MMPs), the significance of each MMP relative to nociception remains …

Emerging evidence implicates the upregulation of matrix metalloproteinase (MMP)-9/2 in the
dorsal root ganglion (DRG) and spinal cord as a contributor to the pathogenesis of chronic …

Background In the peripheral nerve, pro-inflammatory matrix metalloproteinase (MMP)-9
performs essential functions in the acute response to injury. Whether MMP-9 activity …

Matrix metalloproteinases (MMPs) emerge as modulators of neuropathic pain. Because
myelin protects Aβ afferents from ectopic hyperexcitability and nociception from innocuous …

Matrix metalloproteinases (MMPs) have been implicated in the modulation of synaptic
plasticity, glial activation, and long-term potentiation in the CNS. Here we demonstrate for …

Matrix metalloproteinase 9 (MMP9) and MMP2 are important in the development and
maintenance of neuropathic pain behavior induced by peripheral nerve injury. The …

We previously performed transcriptome sequencing and found that genes for matrix
metalloproteinases (MMPs), such as MMP7 and 12, seem to be highly upregulated following …

The balance between expression of matrix metalloproteases (MMPs) and their endogenous
tissue inhibitors (TIMPs) has important implications for the healthy nervous system as well as …

Matrix metalloproteinases (MMPs) are a family of endopeptidases that degrade extracellular
matrix components. Membrane-type 5 MMP (MT5-MMP/MMP-24) was identified as neuron …

Matrix metalloproteinase-9 (MMP-9) is an extracellular protease that is induced in Schwann
cells hours after peripheral nerve injury and controls axonal degeneration and macrophage …