Background Uveal melanoma (UM) is a rare and deadly eye cancer with high metastatic
potential. Despite the predominance of malignant cells within the tumor microenvironment …

Background Uveal melanoma (UM), arising from melanocytes in the choroid, accounts for
3% to 5% of all melanocytic tumors and over 70% of intraocular malignancies. Despite …

Background Uveal melanoma (UM) is the most common primary intraocular malignancy with
a strong tendency to metastasize. The prognosis is poor once metastasis occurs. The …

Purpose Uveal melanoma (UM) is the most common intraocular malignancy in adults.
Previous studies have examined the intra-tumoral heterogeneity. However, the spatial …

Background: Uveal melanoma (UVM) is a form of eye cancer with a poor prognosis,
particularly in metastatic patients. This study aimed to elucidate the cellular heterogeneity …

Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, with a
high propensity for metastasis and, historically, a lack of effective treatment options for late …

Uveal melanoma (UM) is the most common intraocular malignancy in adults. The prognosis
is poor once metastasis has developed. The treatment of metastatic UM remains challenging …

Molecular classification based on transcriptional characteristics is often used to study tumor
heterogeneity. Human cancer has different cell populations with distinct transcription in …

Gene expression profiles as well as genomic imbalances are correlated with disease
progression in uveal melanoma (UM). We integrated expression and genomic profiles to …

Uveal melanoma (UM) is a rare cancer resulting from the transformation of melanocytes in
the uveal tract. Integrative analysis has identified four molecular and clinical subsets of UM …