Apelin‑13 ameliorates metabolic and cardiovascular disorders in a rat model of type 2 diabetes with a high‑fat diet

M Li, H Fang, J Hu - Molecular medicine reports, 2018 - spandidos-publications.com
Apelin has been reported to be associated with multiple physiological processes in the
cardiovascular system. The aim of the present study was to investigate the effects of Apelin …

Effect of apelin on the cardiac hemodynamics in hypertensive rats with heart failure

H Pang, B Han, T Yu, Z Zong - … journal of molecular …, 2014 - spandidos-publications.com
It is known that apelin has definite protective effects on various cardiovascular diseases;
however, the mechanism through which hypertension with heart failure (H-HF) is affected by …

Chronic effects of apelin on cardiovascular regulation and angiotensin II-induced hypertension

Q Zhang, Y Shen, SI Niloy, ST O'Rourke, C Sun - Pharmaceuticals, 2023 - mdpi.com
Apelin, by stimulation of APJ receptors, induces transient blood pressure (BP) reduction and
positive inotropic effects. APJ receptors share high homology with the Ang II type 1 receptor; …

The effects of apelin treatment on a rat model of type 2 diabetes

R Akcılar, S Turgut, V Caner, A Akcılar, C Ayada… - Advances in medical …, 2015 - Elsevier
Purpose Apelin is an adipokine that plays a role in the regulation of many biological
functions in mammals including the neuroendocrine, cardiovascular, immune systems …

Ameliorative effect of apelin on streptozotocin-induced diabetes and its associated cardiac hypertrophy

II Hegab - Alexandria journal of medicine, 2018 - ajol.info
Aim: Apelin, an adipocyte-derived factor, exhibited a number of cardioprotective properties;
however, its effect in diabetes which is a major risk factor for cardiovascular disease (CVD) …

The effect of apelin-13 on pancreatic islet beta cell mass and myocardial fatty acid and glucose metabolism of experimental type 2 diabetic rats

J Feng, H Zhao, M Du, X Wu - Peptides, 2019 - Elsevier
Apelin, a new identified adipokine, and its G protein–coupled receptor named APJ are
widely expressed in various tissues. Apelin has been found to play important roles in the …

Apelin‑13 alleviates diabetic nephropathy by enhancing nitric oxide production and suppressing kidney tissue fibrosis

Z Gao, X Zhong, YX Tan, D Liu - … journal of molecular …, 2021 - spandidos-publications.com
Diabetes is a serious metabolic disease, and the kidney damage induced by diabetes also
seriously affects the survival of patients. Apelin is a molecule that plays a crucial role in lipid …

Beneficial long‐term antidiabetic actions of N‐and C‐terminally modified analogues of apelin‐13 in diet‐induced obese diabetic mice

V Parthsarathy, C Hogg, PR Flatt… - Diabetes, Obesity and …, 2018 - Wiley Online Library
Aims To investigate the chronic effects of twice‐daily administration of stable apelin
analogues, apelin‐13 amide and pyroglutamyl (pGlu) apelin‐13 amide, on metabolic …

[PDF][PDF] Effect of regular exercise-induced apelin on dyslipidemia of type 2 diabetic rats

F Kazemi, K Ebrahim, SZ Asl - Res Med, 2016 - pejouhesh.sbmu.ac.ir
Background: Recently the role of apelin in improvement of dislipidemia has been known.
The purpose of this study was to determine the effect of regular exercise-induced apelin on …

Elevated levels of apelin-36 in heart failure due to chronic systemic hypoxia

F Ferdinal, D Limanan, RD Rini… - … Journal of Angiology, 2019 - thieme-connect.com
Apelin is a novel adipokine identified as an endogenous ligand of the specific orphan
receptor APJ. Among the various isoforms of apelin, an increase in the apelin-36 plasma …