Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR)

BH Brummett, SH Boyle, IC Siegler, CM Kuhn… - Behavior genetics, 2008 - Springer
The short (s) variant of the serotonin transporter (5-HTT) gene linked functional polymorphic
region (5-HTTLPR) is associated with depression. Stressful life events, gender, and race …

Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology

SE Taylor, BM Way, WT Welch, CJ Hilmert… - Biological …, 2006 - Elsevier
BACKGROUND: Mixed evidence has suggested that homozygous carriers of the short allele
(s/s) of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) may be at …

No interaction between the serotonin transporter polymorphism (5‐HTTLPR) and childhood adversity or recent stressful life events on symptoms of depression …

P Chipman, AF Jorm, M Prior, A Sanson… - American Journal of …, 2007 - Wiley Online Library
In this study we investigated interactions between the 5‐HTTLPR genotype and
environmental risk factors (G× E) on symptoms of depression in two large Australian …

The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression

NA Gillespie, JB Whitfield, BEN Williams… - Psychological …, 2005 - cambridge.org
Background. Serotonin is a good candidate for major depression. We attempted to replicate
the study by Caspi and colleagues [Science (2003) 301, 386–389] which reported a …

The serotonin transporter polymorphism (5‐HTTLPR): allelic variation and links with depressive symptoms

N Goldman, DA Glei, YH Lin… - Depression and …, 2010 - Wiley Online Library
Background: We compare the genotype distribution for the serotonin transporter
polymorphism (5‐HTTLPR) in a sample of older Taiwanese adults with samples of various …

Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis

N Risch, R Herrell, T Lehner, KY Liang, L Eaves, J Hoh… - Jama, 2009 - jamanetwork.com
Context Substantial resources are being devoted to identify candidate genes for complex
mental and behavioral disorders through inclusion of environmental exposures following the …

Development of depression: sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene

RL Sjöberg, KW Nilsson, N Nordquist… - International Journal …, 2006 - academic.oup.com
Previous research has demonstrated that a polymorphism in the serotonin transporter gene
(5-HTTLPR) and adverse psychosocial circumstances interact to predict depression. The …

Interaction between serotonin transporter polymorphism (5-HTTLPR) and stressful life events in adolescents' trajectories of anxious/depressed symptoms.

IT Petersen, JE Bates, JA Goodnight… - Developmental …, 2012 - psycnet.apa.org
Abstract Caspi et al.(2003) found an interaction between the serotonin transporter
polymorphism gene (5-HTTLPR) and stressful life events on depression. Subsequent …

Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression

RC Culverhouse, NL Saccone, AC Horton, Y Ma… - Molecular …, 2018 - nature.com
The hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is
associated with increased risk of depression, but only in individuals exposed to stressful …

Serotonin transporter length polymorphism, childhood maltreatment, and chronic depression: a specific gene–environment interaction

GW Brown, M Ban, TKJ Craig, TO Harris… - Depression and …, 2013 - Wiley Online Library
Background Key questions about the interaction between the serotonin transporter length
polymorphism (5‐HTTLPR) and stress in the etiology of depression remain unresolved. We …