Simple Summary Currently, there is no effective treatment that can cure metastatic prostate
cancer. Various pros-tate specific membrane antigen (PSMA)-targeted radioimaging and …

Background Prostate‐specific membrane antigen (PSMA) is a well‐characterized target that
is overexpressed selectively on prostate cancer cells. PSMA antibody‐drug conjugate (ADC) …

Prostate-specific membrane antigen (PSMA) is a promising target for the treatment of
advanced prostate cancer (PC) and various solid tumors. Although PSMA-targeted …

Prostate-specific membrane antigen (PSMA) is a membrane protein that is overexpressed
manifold in prostate cancer and provides an attractive target for therapy. PSMA ADC is an …

Most patients with advanced prostate cancer (PCa) will develop metastatic castration-
resistant prostate cancer (mCRPC) after androgen deprivation therapy, at this time the tumor …

Cell-surface markers of prostate cancer 3. PSMA as a target for cancer therapy 4. Antibody-
drug conjugate chemistries 5. Preclinical findings 5.1. PSMA ADC 5.2. MLN2704 5.3 …

Prostate cancer (PC) is a potentially high-risk disease and the most common cancer in
American men. It is a leading cause of cancer-related deaths in men in the US, second only …

Prostate-specific membrane antigen (PSMA) is a type II membrane glycoprotein
overexpressed in a variety of tumors, especially in nearly all prostate cancers, which makes …

119 Background: The abundant expression of prostate specific membrane antigen (PSMA)
on prostate cancer cells provides a rationale for antibody therapy. PSMA ADC, a fully human …

Cancer cells can be selectively targeted by identifying and developing antibodies to specific
antigens present on the cancer cell surface. Cytotoxic agents can be conjugated to these …