Adenoviral vectors have been explored as vaccine agents for a range of infectious diseases,
and their ability to induce a potent and balanced immune response made them logical …

The coronavirus disease (COVID-19) breakout had an unimaginable worldwide effect in the
21st century, claiming millions of lives and putting a huge burden on the global economy …

Highlights•The safety of adenoviral vector vaccines is now well-established•Viral vector
vaccines are the only licensed vaccines against Ebola virus.•Adenoviral vector vaccines are …

The worldwide pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the unprecedented pace of …

Zoonotic viruses continually pose a pandemic threat. Infection of humans with viruses for
which we typically have little or no prior immunity can result in epidemics with high morbidity …

Most of us might be surprised by the rudimentary scientific rationale prevalent in the field of
vaccine research just 50 years ago. For over a century after Louis Pasteur's vaccine against …

Vaccine development against SARS-CoV-2 has been fierce due to the devastating COVID-
19 pandemic and has included all potential approaches for providing the global community …

Background A vaccine to protect against COVID-19 is urgently needed. We aimed to assess
the safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 (Ad5) …

Replication-incompetent adenovirus (Ad) vectors have been widely used as gene delivery
vehicles in both gene therapy studies and basic studies for gene function analysis due to …

Emerging coronaviruses (CoV) are constant global public health threats to society. Multiple
ongoing clinical trials for vaccines and antivirals against CoVs showcase the availability of …